HLA-DRB1 产品
(Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))
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HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Featured HLA-DRB1 Categories
HLA-DRB1 抗体
High quality antibodies with extensive validation data.
HLA-DRB1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HLA-DRB1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DRB1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440764
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, FACS, IF, IHC, ISt, StM
Validations
- (6)
Cat. No.
ABIN6939640
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440767
Quantity
100 μL
Datasheet
Datasheet
Recommended HLA-DRB1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960713
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6960714
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN2948352
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-DRB1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5853579
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412938
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412935
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HLA-DRB1 Products
: "Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration." in: Aging, Vol. 9, Issue 3, pp. 823-851, (2017) (PubMed).: "DRB1*15 allele is a risk factor for PR3-ANCA disease in African Americans." in: Journal of the American Society of Nephrology : JASN, Vol. 22, Issue 6, pp. 1161-7, (2011) (PubMed).
: "Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles." in: Immunogenetics, Vol. 59, Issue 4, pp. 261-71, (2007) (PubMed).
: "Ancient haplotypes of the HLA Class II region." in: Genome research, Vol. 15, Issue 9, pp. 1250-7, (2005) (PubMed).
: "Evolution of the HLA-DR1 gene family. Structural and functional analysis of the new allele "DR-BON"." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 3, pp. 984-9, (1990) (PubMed).
: "DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 10, pp. 3405-9, (1985) (PubMed).
Synonyms and alternative names related to HLA-DRB1
major histocompatibility complex, class II, DR beta 1 (hla-drb1), major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), DRB1, DRw10, HLA-DR1B, HLA-DRB, MGC108235, SS1Protein level used designations for HLA-DRB1
- major histocompatibility complex, class II, DR beta 1
- DW2.2/DR2.2
- HLA class II histocompatibility antigen, DR-1 beta chain
- MHC class II HLA-DR beta 1 chain
- MHC class II HLA-DR-beta cell surface glycoprotein
- MHC class II HLA-DRw10-beta
- MHC class II antigen
- human leucocyte antigen DRB1
- lymphocyte antigen DRB1
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