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Haptoglobin 蛋白

(Haptoglobin (HP))

This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

recommended

Haptoglobin Protein (HP) (AA 145-405) (His tag) (ABIN7123252)

HP 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

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recommended

Haptoglobin Protein (HP) (AA 1-281) (GST tag) (ABIN1307018)

HP 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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recommended

Haptoglobin Protein (HP) (Phenotype 1-1) (ABIN3119693)

HP 宿主: 人宿主: Human Native >95 %

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Haptoglobin 蛋白 by Origin

Find Haptoglobin 蛋白 for a variety of species such as anti-Human Haptoglobin, anti-Rat Haptoglobin, anti-Cow Haptoglobin. The species listed below are among those available. Click on a link to go to the corresponding products.

Haptoglobin 蛋白 by Source

Here you will find Haptoglobin 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

Haptoglobin 蛋白 by 蛋白类型

Here you can find Haptoglobin 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

Haptoglobin 蛋白 by 应用范围

Find Haptoglobin 蛋白 validated for a specific application such as SDS, ELISA, WB, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Haptoglobin 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Haptoglobin Protein (HP) (AA 145-405) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7123252

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 1-281) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1307018

Quantity 10 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (Phenotype 1-1)

Reactivity Human

Source Human

Validations

Cat. No. ABIN3119693

Quantity 1 mg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 118-281) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7505808

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 19-160, AA 162-406) (His tag)

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN7318556

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 145-406) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7318557

Quantity 50 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 123-307) (His tag)

Reactivity Pig

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392224

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 44-157) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392218

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 168-319) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7402730

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 70-332) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7411354

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 125-297) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7392227

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 104-346) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7417549

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 70-332) (His tag)

Reactivity Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7417552

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 21-98) (His tag)

Reactivity Rabbit

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7403276

Quantity 100 μg

Datasheet Datasheet

Haptoglobin Protein (HP) (AA 177-342) (His tag)

Reactivity Rabbit

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7402355

Quantity 100 μg

Datasheet Datasheet

Latest Publications for our Haptoglobin 蛋白

Pirschel, Mestekemper, Wissuwa, Krieg, Kröller, Daniel, Gunzer, Tolosano, Bauer, Amann, Heinemann, Coldewey: "Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice." in: Kidney international, (2022) (PubMed).

Eshbach, Kaur, Rbaibi, Tejero, Weisz: "Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease." in: American journal of physiology. Cell physiology, Vol. 312, Issue 6, pp. C733-C740, (2017) (PubMed).

Kozlik, Goldman, Sanda: "Study of structure-dependent chromatographic behavior of glycopeptides using reversed phase nanoLC." in: Electrophoresis, Vol. 38, Issue 17, pp. 2193-2199, (2017) (PubMed).

Sakamoto, Kim, Hara, Kamada, Caballero-Flores, Tolosano, Soares, Puente, Inohara, Núñez: "IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections." in: Science immunology, Vol. 2, Issue 8, (2017) (PubMed).

Fatunmbi, Abzalimov, Savinov, Gershenson, Kaltashov: "Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry." in: Biochemistry, Vol. 55, Issue 12, pp. 1918-28, (2016) (PubMed).

Chen-Roetling, Regan: "Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin." in: Journal of neurochemistry, Vol. 139, Issue 4, pp. 586-595, (2016) (PubMed).

Almeida, Souza, Leonardo, Costa, Werneck, Covas, Costa, Conran: "Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea." in: Blood, Vol. 126, Issue 6, pp. 711-20, (2015) (PubMed).

Zapotoczna, Heilbronner, Speziale, Foster: "Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis." in: Journal of bacteriology, Vol. 194, Issue 23, pp. 6453-67, (2012) (PubMed).

Aliases for Haptoglobin 蛋白

haptoglobin (HP) 蛋白
haptoglobin (hp) 蛋白
haptoglobin (Hp) 蛋白
haptoglobin-like (LOC479668) 蛋白
haptoglobin (LOC101102413) 蛋白
BP 蛋白
HP 蛋白
HP-1 蛋白
HP2ALPHA2 蛋白
HPA1S 蛋白
HPR 蛋白
wu:fb64e01 蛋白
Zonulin 蛋白

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Haptoglobin 蛋白 by Origin

Haptoglobin 蛋白 by Source

Haptoglobin 蛋白 by 蛋白类型

Haptoglobin 蛋白 by 应用范围

Popular Haptoglobin 蛋白

Latest Publications for our Haptoglobin 蛋白

Aliases for Haptoglobin 蛋白

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