GSTM3 产品
(Glutathione S-Transferase mu 3 (Brain) (GSTM3))
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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].
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Latest Publications for our GSTM3 Products
: "Human Glutathione S-Transferase Enzyme Gene Polymorphisms and Their Association With Neurocysticercosis." in: Molecular neurobiology, (2016) (PubMed).: "Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases." in: Chemical research in toxicology, Vol. 27, Issue 12, pp. 2071-81, (2014) (PubMed).
: "Gene variations in GSTM3 are a risk factor for Alzheimer's disease." in: Neurobiology of aging, Vol. 30, Issue 5, pp. 691-6, (2009) (PubMed).
Synonyms and alternative names related to GSTM3
glutathione S-transferase mu 3 (GSTM3), glutathione S-transferase Mu 3 (GSTM3), glutathione S-transferase, mu 3 (Gstm3), glutathione S-transferase Mu 3 (LOC479911), glutathione S-transferase mu 3 (Gstm3), Fsc2, GST5, GSTB, GSTM3-3, GTM3, mGSTM5Protein level used designations for GSTM3
- GST class-mu 3
- S-(hydroxyalkyl)glutathione lyase M3
- brain GST
- brain type mu-glutathione S-transferase
- glutathione S-alkyltransferase M3
- glutathione S-aralkyltransferase M3
- glutathione S-aryltransferase M3
- glutathione S-transferase M3 (brain)
- glutathione S-transferase Mu 3
- glutathione S-transferase, Mu-3
- hGSTM3-3
- glutathione S-transferase M3
- glutathione S-transferase GT9.3
- glutathione S-transferase mu 3
- glutathione-S-transferase, mu
- glutathione S-transferase Mu 3-like
- glutathione S-transferase Mu 5
- GST class-mu 5
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