GRK2 产品
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Categories
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008].
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Featured GRK2 Categories
GRK2 抗体
High quality antibodies with extensive validation data.
GRK2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GRK2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GRK2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (6)
Cat. No.
ABIN3022346
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, ICC, FACS, IP
Validations
- (6)
Cat. No.
ABIN2855125
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC
Validations
- (2)
- (4)
Cat. No.
ABIN969178
Quantity
100 μL
Datasheet
Datasheet
Recommended GRK2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964660
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964661
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964659
Quantity
96 tests
Datasheet
Datasheet
Recommended GRK2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344492
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508944
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
Cat. No.
ABIN7317491
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our GRK2 Products
: "Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study." in: Scientific reports, Vol. 8, Issue 1, pp. 12731, (2018) (PubMed).: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." in: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).
: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." in: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).
: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, (2008) (PubMed).
: "Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure." in: European heart journal, Vol. 26, Issue 17, pp. 1752-8, (2005) (PubMed).
: "The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8052-7, (2003) (PubMed).
: "Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30219-26, (2003) (PubMed).
: "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated ..." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18658-63, (2003) (PubMed).
: "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase." in: World journal of gastroenterology : WJG, Vol. 9, Issue 4, pp. 800-3, (2003) (PubMed).
: "Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells." in: Anesthesiology, Vol. 98, Issue 2, pp. 343-8, (2003) (PubMed).
Synonyms and alternative names related to GRK2
beta-adrenergic receptor kinase 1 (Tsp_00497), G protein-coupled receptor kinase 2 (grk2), G protein-coupled receptor kinase 2 (Grk2), G protein-coupled receptor kinase 2 (GRK2), Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, GRK2, Grk2Protein level used designations for GRK2
- beta-adrenergic receptor kinase 1
- adrenergic, beta, receptor kinase 1
- G-protein-coupled receptor kinase 2
- beta ARK
- beta ARK1
- beta-AR kinase-1
- beta-ARK-1
- beta-adrenergic receptor kinase-1
- G-protein coupled receptor kinase 2
- adrenergic receptor kinase, beta 1
- beta-adrenergic receptor kinase 1 beta ARK1
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