GREM1 产品
(Gremlin 1 (GREM1))
Categories
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Featured GREM1 Categories
GREM1 抗体
High quality antibodies with extensive validation data.
GREM1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GREM1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GREM1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (5)
Cat. No.
ABIN687082
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (9)
- (7)
Cat. No.
ABIN390078
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7434692
Quantity
100 μL
Datasheet
Datasheet
Recommended GREM1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (9)
- (6)
Cat. No.
ABIN6730963
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962271
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967209
Quantity
96 tests
Datasheet
Datasheet
Recommended GREM1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (2)
Cat. No.
ABIN4949105
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123201
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our GREM1 Products
: "Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells." in: Journal of diabetes research, Vol. 2020, pp. 9238742, (2021) (PubMed).: "Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis." in: Scientific reports, Vol. 9, Issue 1, pp. 6867, (2020) (PubMed).
: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." in: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).
: "Platelets as a novel source of Gremlin-1: Implications for thromboinflammation." in: Thrombosis and haemostasis, Vol. 117, Issue 2, pp. 311-324, (2018) (PubMed).
: "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells." in: European cells & materials, Vol. 33, pp. 197-210, (2017) (PubMed).
: "Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. ..." in: Scientific reports, Vol. 7, pp. 44941, (2017) (PubMed).
: "Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells." in: Molecular medicine reports, Vol. 15, Issue 4, pp. 2186-2194, (2017) (PubMed).
: "Overexpression of Gremlin promotes non-small cell lung cancer progression." in: Tumour biology, Vol. 37, Issue 2, pp. 2597-602, (2016) (PubMed).
: "GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness." in: The Journal of rheumatology, Vol. 43, Issue 3, pp. 474-85, (2016) (PubMed).
: "Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension." in: American journal of respiratory cell and molecular biology, Vol. 55, Issue 4, pp. 564-575, (2016) (PubMed).
Synonyms and alternative names related to GREM1
gremlin 1a, DAN family BMP antagonist (grem1a), gremlin 1, DAN family BMP antagonist (GREM1), gremlin 1 (LOC662541), gremlin 1, DAN family BMP antagonist (grem1), gremlin 1, DAN family BMP antagonist (Grem1), gremlin 1, DAN family BMP antagonist L homeolog (grem1.L), Cktsf1b1, CKTSF1B1, cktsf1b1, dand2, DAND2, drm, Drm, DRM, Grem, grem1, GREM1, gremlin, GREMLIN, gremlin-1, ihg-2, IHG-2, ld, MGC136702, pig2, zgc:136702Protein level used designations for GREM1
- gremlin 1 homolog a, cysteine knot superfamily
- gremlin 1 homolog, cysteine knot superfamily
- gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
- gremlin 1
- GLEAN_07044
- cysteine knot superfamily 1
- cysteine knot superfamily 1, BMP antagonist 1
- down-regulated in Mos-transformed cells protein
- down-regulated in v-mos-transformed cells
- gremlin-1
- gremlin 1, cysteine knot superfamily, homolog
- Cysteine knot superfamily 1, BMP antagonist 1
- DAN domain family member 2
- cell proliferation-inducing gene 2 protein
- gremlin 1-like protein
- increased in high glucose-2
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