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GNAT3 产品

(Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))

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Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.

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Featured GNAT3 Categories

GNAT3 抗体

High quality antibodies with extensive validation data.

GNAT3 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GNAT3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7243340
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7154719
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN7267544
Quantity 100 μL
Datasheet Datasheet

Recommended GNAT3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2722098
Quantity 20 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1474568
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1459575
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our GNAT3 Products

Jang, Kokrashvili, Theodorakis, Carlson, Kim, Zhou, Kim, Xu, Chan, Juhaszova, Bernier, Mosinger, Margolskee, Egan: "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 38, pp. 15069-74, (2007) (PubMed).

Ma, Sheng, Zhang, Zhang, He, Huang, Chen, Sultz, Adegboyega, Zhang, Xie: "Hedgehog signaling is activated in subsets of esophageal cancers." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 1, pp. 139-48, (2005) (PubMed).

Synonyms and alternative names related to GNAT3

G protein subunit alpha transducin 3 (GNAT3), guanine nucleotide binding protein, alpha transducing 3 (Gnat3), G protein subunit alpha transducin 3 (Gnat3), GDCA, Ggust, gnat-3, Gtn

Protein level used designations for GNAT3

  • guanine nucleotide-binding protein G(t) subunit alpha-3
  • gustducin
  • guanine nucleotide binding protein, alpha transducing 3
  • guanine nucleotide-binding protein G(t) subunit alpha-3-like
  • gustducin alpha-3 chain
  • alpha-gustducin
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