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GLA 产品

(Galactosidase, alpha (GLA))

Categories

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008].

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Featured GLA Categories

GLA 抗体

High quality antibodies with extensive validation data.

GLA ELISA试剂盒

Reliable ELISA kits for a wide range of species.

GLA 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GLA 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7431278
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7426817
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP, IHC (p)
Validations
  • (2)
  • (5)
Cat. No. ABIN2854962
Quantity 100 μL
Datasheet Datasheet

Recommended GLA ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6720556
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN3199196
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1050151
Quantity 96 tests
Datasheet Datasheet

Recommended GLA 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1355176
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123037
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7320092
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our GLA Products

Ivanova, Dao, Kasaci, Adewale, Fikry, Goker-Alpan: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." in: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).

Hingorani, Metcalf, Deming, Garman, Powers, Gierasch: "Ligand-promoted protein folding by biased kinetic partitioning." in: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).

Smith, Jäntti, Oja, Saloheimo: "Comparison of intracellular and secretion-based strategies for production of human ?-galactosidase A in the filamentous fungus Trichoderma reesei." in: BMC biotechnology, Vol. 14, pp. 91, (2015) (PubMed).

Xu, Lun, Brignol, Hamler, Schilling, Frascella, Sullivan, Boyd, Chang, Soska, Garcia, Feng, Yasukawa, Shardlow, Churchill, Ketkar, Robertson, Miyamoto, Mihara, Benjamin, Lockhart, Hirato, Fowles et al.: "Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice. ..." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 7, pp. 1169-81, (2015) (PubMed).

Shu, Vivekanandan-Giri, Pennathur, Smid, Aerts, Hollak, Shayman: "Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease." in: Kidney international, Vol. 86, Issue 1, pp. 58-66, (2014) (PubMed).

Andreotti, Citro, Correra, Cubellis: "A thermodynamic assay to test pharmacological chaperones for Fabry disease." in: Biochimica et biophysica acta, Vol. 1840, Issue 3, pp. 1214-24, (2014) (PubMed).

Corchero, Mendoza, Lorenzo, Rodríguez-Sureda, Domínguez, Vázquez, Ferrer-Miralles, Villaverde: "Integrated approach to produce a recombinant, His-tagged human ?-galactosidase A in mammalian cells." in: Biotechnology progress, Vol. 27, Issue 5, pp. 1206-17, (2011) (PubMed).

Pilon, Schekman: "Protein translocation: how Hsp70 pulls it off." in: Cell, Vol. 97, Issue 6, pp. 679-82, (1999) (PubMed).

Bukau, Horwich: "The Hsp70 and Hsp60 chaperone machines." in: Cell, Vol. 92, Issue 3, pp. 351-66, (1998) (PubMed).

Hang, Fox: "Expression of hsp70 induced in CHO cells by 45.0 degrees C hyperthermia is cell cycle associated and DNA synthesis dependent." in: Cytometry, Vol. 19, Issue 2, pp. 119-25, (1995) (PubMed).

Synonyms and alternative names related to GLA

galactosidase alpha (GLA), galactosidase, alpha (Gla), galactosidase, alpha (gla), galactosidase alpha S homeolog (gla.S), galactosidase alpha (gla), alpha-galactosidase (agaN), aga (aga), alpha-galactosidase (agaL), alpha-galactosidase (SCO0541), alpha-galactosidase (rafA), alpha-galactosidase (melA), alpha-galactosidase (galA), alpha-galactosidase A (ANI_1_2528074), alpha-galactosidase A (ANI_1_1502124), alpha-galactosidase A (AOR_1_390174), alpha-galactosidase A (CpipJ_CPIJ002066), alpha-galactosidase (aga), alpha-galactosidase A (MCYG_00962), alpha-galactosidase A (MCYG_00791), alpha-galactosidase (gla), alpha-galactosidase A (Tsp_02909), alpha-galactosidase A (Tsp_02508), galactosidase alpha (Gla), galactosidase, alpha (GLA), Ags, alpha-GAL, AO090005000217, GALA, MGC130872, SCF11.21, SMU.877, zgc:101584

Protein level used designations for GLA

  • agalsidase alfa
  • alpha-D-galactosidase A
  • alpha-D-galactoside galactohydrolase 1
  • alpha-gal A
  • alpha-galactosidase A
  • melibiase
  • alpha-D-galactoside galactohydrolase
  • Alpha-galactosidase A
  • galactosidase, alpha
  • alpha-galactosidase A-like
  • alpha-galactosidase
  • Alpha-galactosidase
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