GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008].
Du, Teng, Lawrence, Guan, Xu, Ge, Shi: "The protein partners of GTP cyclohydrolase I in rat organs." in: PLoS ONE, Vol. 7, Issue 3, pp. e33991, (2012) (PubMed).