G6PC 产品
(Glucose 6-Phosphatase, Catalytic (G6PC))
Categories
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011].
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Featured G6PC Categories
G6PC 抗体
High quality antibodies with extensive validation data.
G6PC ELISA试剂盒
Reliable ELISA kits for a wide range of species.
G6PC 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended G6PC 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (1)
- (6)
Cat. No.
ABIN2781770
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (4)
Cat. No.
ABIN651417
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (3)
- (3)
Cat. No.
ABIN2781769
Quantity
100 μL
Datasheet
Datasheet
Recommended G6PC ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956119
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956120
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956121
Quantity
96 tests
Datasheet
Datasheet
Recommended G6PC 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354607
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409233
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399592
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our G6PC Products
: "Berberine inhibits gluconeogenesis in spontaneous diabetic rats by regulating the AKT/MAPK/NO/cGMP/PKG signaling pathway." in: Molecular and cellular biochemistry, (2023) (PubMed).: "Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction." in: Cell metabolism, Vol. 30, Issue 6, pp. 1141-1151.e5, (2019) (PubMed).
: "Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates." in: Nature medicine, Vol. 23, Issue 4, pp. 439-449, (2017) (PubMed).
: "Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling." in: Nature communications, Vol. 7, pp. 10592, (2016) (PubMed).
: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." in: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).
: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).
: "Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation." in: Molecular & cellular proteomics : MCP, Vol. 12, Issue 10, pp. 2689-700, (2013) (PubMed).
: "Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis." in: PLoS ONE, Vol. 8, Issue 7, pp. e70309, (2013) (PubMed).
Synonyms and alternative names related to G6PC
glucose-6-phosphatase, catalytic (G6pc), glucose-6-phosphatase catalytic subunit (G6PC), glucose-6-phosphatase, catalytic subunit (G6pc), AW107337, G-6-Pase, G6Pase, G6PC1, G6pt, G6PT, Glc-6-Pase, GSD1, GSD1aProtein level used designations for G6PC
- G-6-Pase
- Glc-6-Pase-alpha
- glucose-6-phosphatase
- G6Pase
- G6Pase-alpha
- glucose-6-phosphatase alpha
- glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)
- glucose-6-phosphatase catalytic subunit
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