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GALE 产品

(UDP-Galactose-4-Epimerase (GALE))

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This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008].

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Featured GALE Categories

GALE 抗体

High quality antibodies with extensive validation data.

GALE ELISA试剂盒

Reliable ELISA kits for a wide range of species.

GALE 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GALE 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Human, Monkey, Rat
Application WB, IHC, IHC (p)
Validations
  • (11)
Cat. No. ABIN1498366
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (6)
Cat. No. ABIN5693266
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7174611
Quantity 100 μg
Datasheet Datasheet

Recommended GALE ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1165298
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1165299
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1165300
Quantity 96 tests
Datasheet Datasheet

Recommended GALE 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125646
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354710
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7319157
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our GALE Products

Macauley, Chan, Zandberg, He, Whitworth, Stubbs, Yuzwa, Bennet, Varki, Davies, Vocadlo et al.: "Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate ..." in: The Journal of biological chemistry, Vol. 287, Issue 34, pp. 28882-97, (2012) (PubMed).

Synonyms and alternative names related to GALE

UDP-galactose-4-epimerase (GALE), UDP-galactose-4-epimerase (gale), NAD(P)-binding Rossmann-fold superfamily protein (RHD1), UDP-galactose-4-epimerase (ECs0787), UDP-galactose-4-epimerase (galE), UDP-galactose 4-epimerase GalE (galE), UDP-glucose 4-epimerase (galE1), UDP-glucose 4-epimerase (galE2), UDP-glucose 4-epimerase GalE (galE), UDP-glucose 4-epimerase (STY0809), UDP-glucose 4-epimerase (galE), UDP-glucose/UDP-N-acetylglucosamine 4-epimerase (galE), UDP-glucose 4-epimerase (galE-2), UDP-galactose-4-epimerase (SG0897), UDP-galactose-4-epimerase (galD), UDP-galactose-4-epimerase (Ent638_1250), galactose-4-epimerase, UDP (Gale), UDP-galactose-4-epimerase L homeolog (gale.L), UDP-galactose-4-epimerase (Gale), 1n569, 2310002A12Rik, AI323962, BA5505, BA5700, ECK0748, F15H21.11, F15H21_11, galD, GALE, galE, im:7147391, JW0742, REB1, ROOT EPIDERMAL BULGER1, ROOT HAIR DEFECTIVE 1, SDR1E1, SMU.888, UDP-GLUCOSE 4-EPIMERASE, UGE4, VFA0352, wu:fb05f01, xgale, zgc:136578

Protein level used designations for GALE

  • UDP-galactose-4-epimerase
  • UDP-glucose 4-epimerase
  • fb05f01
  • UDP-galactose 4-epimerase
  • galactowaldenase
  • UDP-glucose (37.7 kD) (1N569)
  • UDP galactose-4'-epimerase
  • galactose-4-epimerase, UDP-
  • short chain dehydrogenase/reductase family 1E, member 1
  • galactose-4-epimerase, UDP
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