GAD65 产品
(Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008].
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Featured GAD65 Categories
GAD65 抗体
High quality antibodies with extensive validation data.
GAD65 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GAD65 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GAD65 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433339
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (6)
Cat. No.
ABIN949999
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
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- (5)
Cat. No.
ABIN7437707
Quantity
100 μL
Datasheet
Datasheet
Recommended GAD65 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6967053
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967052
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
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Cat. No.
ABIN6956137
Quantity
96 tests
Datasheet
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Recommended GAD65 蛋白
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Source
Wheat germ
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- (1)
Cat. No.
ABIN1354671
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
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Cat. No.
ABIN7320201
Quantity
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Datasheet
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Latest Publications for our GAD65 Products
: "Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy." in: The Journal of cell biology, Vol. 215, Issue 2, pp. 245-258, (2016) (PubMed).: "Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease." in: Neuroscience, Vol. 329, pp. 363-79, (2016) (PubMed).
: "Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling." in: Molecular brain, Vol. 9, pp. 32, (2016) (PubMed).
: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).
: "Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes." in: Frontiers in cellular neuroscience, Vol. 9, pp. 120, (2015) (PubMed).
: "Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22593-601, (2015) (PubMed).
: "Acrylamide neurotoxicity on the cerebrum of weaning rats." in: Neural regeneration research, Vol. 10, Issue 6, pp. 938-43, (2015) (PubMed).
: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).
: "Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons." in: Neuroscience, Vol. 246, pp. 451-67, (2013) (PubMed).
: "Prenatal stress affects network properties of rat hippocampal neurons." in: Biological psychiatry, Vol. 73, Issue 11, pp. 1095-102, (2013) (PubMed).
Synonyms and alternative names related to GAD65
glutamate decarboxylase 2 (GAD2), glutamate decarboxylase 2 (PTRG_06148), glutamate decarboxylase 2 (LOC9324534), glutamate decarboxylase 2 (Gad2), glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 2 (gad2), glutamic acid decarboxylase 2 (Gad2), 6330404F12Rik, F12P19.12, F12P19_12, GAD(65), Gad-2, GAD65, gad65, GLUTAMATE DECARBOXYLASE 2, glutamate decarboxylase 2, zgc:112198Protein level used designations for GAD65
- glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
- glutamate decarboxylase 2
- glutamic acid decarboxylase
- 65 kDa glutamic acid decarboxylase
- GAD-65
- Glutamate decarboxylase 2 (islet)
- glutamate decarboxylase 65 kDa isoform
- glutamic acid decarboxylase 2
- glutamic acid decarboxylase 65
- Glutamate decarboxylase-2 (pancreas)
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