GAD 产品
(Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))
Categories
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008].
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Featured GAD Categories
GAD 抗体
High quality antibodies with extensive validation data.
GAD ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GAD 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GAD 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN3017019
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IHC (p), IF, IHC (fro), IHC (ff), IHC (wm)
Validations
- (7)
Cat. No.
ABIN2855214
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7437155
Quantity
100 μL
Datasheet
Datasheet
Recommended GAD ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6574313
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
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- (1)
Cat. No.
ABIN6967049
Quantity
96 tests
Datasheet
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Reactivity
Rat
Analytical Method
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Cat. No.
ABIN6967051
Quantity
96 tests
Datasheet
Datasheet
Recommended GAD 蛋白
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354667
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505296
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7401104
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our GAD Products
: "A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme." in: Scientific reports, Vol. 8, Issue 1, pp. 15470, (2018) (PubMed).: "Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex." in: PLoS ONE, Vol. 11, Issue 2, pp. e0149004, (2016) (PubMed).
: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).
: "Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing." in: Frontiers in cellular neuroscience, Vol. 9, pp. 159, (2015) (PubMed).
: "Characterization of continuous B-cell epitopes in the N-terminus of glutamate decarboxylase67 using monoclonal antibodies." in: Journal of peptide science : an official publication of the European Peptide Society, Vol. 20, Issue 12, pp. 928-34, (2014) (PubMed).
: "Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome." in: Neurobiology of disease, Vol. 63, pp. 92-106, (2014) (PubMed).
: "Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain." in: Brain structure & function, Vol. 219, Issue 3, pp. 843-60, (2014) (PubMed).
: "Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD)." in: Neuroscience letters, Vol. 537, pp. 50-4, (2013) (PubMed).
: "High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission." in: American journal of physiology. Endocrinology and metabolism, Vol. 302, Issue 4, pp. E396-402, (2012) (PubMed).
: "Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice." in: Neuroscience, Vol. 189, pp. 108-22, (2011) (PubMed).
Synonyms and alternative names related to GAD
glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 1 L homeolog (gad1.1.L), glutamate decarboxylase (GAD), glutamate decarboxylase 1 (Gad1), glutamate decarboxylase 1b (gad1b), CPSQ1, cpsq1, EP10, GAD, Gad-1, GAD-67, gad1, GAD1, gad1-A, GAD25, GAD44, gad67, GAD67, Gad67, GLUTAMATE DECARBOXYLASE, glutamate decarboxylase, GLUTAMATE DECARBOXYLASE 1, MKP11.30, MKP11_30, SCPProtein level used designations for GAD
- 67 kDa glutamic acid decarboxylase
- GAD-67
- glutamate decarboxylase 1
- glutamate decarboxylase 67 kDa isoform
- glutamic acid decarboxylase
- glutamate decarboxylase, 67 kDa isoform
- glutamic acid decarboxylase 1
- glutamate decarboxylase 67
- GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE)
- Glutamate decarboxylase 1 (brain)
- glutamate decarboxylase 1 variant GAD67NT
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