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GABRA5 产品

(gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))

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GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008].

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Featured GABRA5 Categories

GABRA5 抗体

High quality antibodies with extensive validation data.

GABRA5 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GABRA5 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA
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  • (2)
Cat. No. ABIN7153488
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7127506
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, IHC, ICC
Validations
  • (3)
Cat. No. ABIN1742462
Quantity 50 μg
Datasheet Datasheet

Recommended GABRA5 蛋白

Product
Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity Human
Source Wheat germ
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Cat. No. ABIN1354652
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7421713
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2712290
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our GABRA5 Products

You, Vandegrift, Zhang, Lasek, Pandey, Brodie: "Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ-Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal." in: Alcoholism, clinical and experimental research, (2018) (PubMed).

Lu, Liu, Jiang, Pan, Ho, Ho: "Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain." in: Neural plasticity, Vol. 2017, pp. 5715816, (2017) (PubMed).

Botta, Demmou, Kasugai, Markovic, Xu, Fadok, Lu, Poe, Xu, Cook, Rudolph, Sah, Ferraguti, Lüthi: "Regulating anxiety with extrasynaptic inhibition." in: Nature neuroscience, Vol. 18, Issue 10, pp. 1493-500, (2015) (PubMed).

Blednov, Walker, Iyer, Homanics, Harris: "Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol." in: Addiction biology, Vol. 15, Issue 1, pp. 45-61, (2009) (PubMed).

Maison, Rosahl, Homanics, Liberman: "Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 40, pp. 10315-26, (2006) (PubMed).

Pinna, Agis-Balboa, Zhubi, Matsumoto, Grayson, Costa, Guidotti: "Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 11, pp. 4275-80, (2006) (PubMed).

Pöltl, Hauer, Fuchs, Tretter, Sieghart: "Subunit composition and quantitative importance of GABA(A) receptor subtypes in the cerebellum of mouse and rat." in: Journal of neurochemistry, Vol. 87, Issue 6, pp. 1444-55, (2004) (PubMed).

Ogris, Pöltl, Hauer, Ernst, Oberto, Wulff, Höger, Wisden, Sieghart: "Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit." in: Biochemical pharmacology, Vol. 68, Issue 8, pp. 1621-9, (2004) (PubMed).

Brandon, Jovanovic, Colledge, Kittler, Brandon, Scott, Moss: "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits." in: Molecular and cellular neurosciences, Vol. 22, Issue 1, pp. 87-97, (2003) (PubMed).

McKernan, Rosahl, Reynolds, Sur, Wafford, Atack, Farrar, Myers, Cook, Ferris, Garrett, Bristow, Marshall, Macaulay, Brown, Howell, Moore, Carling, Street, Castro, Ragan, Dawson, Whiting: "Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype." in: Nature neuroscience, Vol. 3, Issue 6, pp. 587-92, (2000) (PubMed).

Synonyms and alternative names related to GABRA5

gamma-aminobutyric acid type A receptor alpha5 subunit (GABRA5), gamma-aminobutyric acid (GABA) A receptor, alpha 5 (gabra5), gamma-aminobutyric acid type A receptor alpha 5 subunit (Gabra5), gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 (Gabra5), gamma-aminobutyric acid receptor subunit alpha-5 (LOC100653497), A230018I05Rik, GABRA5, si:dkey-93p24.1

Protein level used designations for GABRA5

  • gamma-aminobutyric acid (GABA) A receptor, alpha 5
  • gamma-aminobutyric acid A receptor, alpha 5-like
  • gamma-aminobutyric acid receptor subunit alpha-5-like
  • GABA(A) receptor subunit alpha-5
  • GABA-A receptor alpha-5 subunit
  • gamma-aminobutyric acid A receptor, alpha 5
  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5
  • gamma-aminobutyric acid A receptor, alpha 5
  • gamma-aminobutyric acid receptor subunit alpha-5
  • GABAA receptor alpha5 subunit
  • ligand-gated ion channel subunit
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