GAB2 产品
(GRB2-Associated Binding Protein 2 (GAB2))
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This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
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Featured GAB2 Categories
GAB2 抗体
High quality antibodies with extensive validation data.
GAB2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
GAB2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GAB2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN685273
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN685288
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7154436
Quantity
100 μg
Datasheet
Datasheet
Recommended GAB2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380840
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380841
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6217340
Quantity
96 tests
Datasheet
Datasheet
Recommended GAB2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354623
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7416967
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092725
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GAB2 Products
: "K48-Linked Ubiquitination Contributes to Nicotine-Augmented Bone Marrow-Derived Dendritic-Cell-Mediated Adaptive Immunity." in: Vaccines, Vol. 9, Issue 3, (2021) (PubMed).: "PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation." in: Journal of immunology research, Vol. 2018, pp. 5070573, (2018) (PubMed).
: "Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model." in: Synapse (New York, N.Y.), Vol. 68, Issue 4, pp. 168-77, (2014) (PubMed).
: "In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 3, pp. 1102-7, (2014) (PubMed).
: "Gab2-mediated signaling promotes melanoma metastasis." in: The American journal of pathology, Vol. 174, Issue 4, pp. 1524-33, (2009) (PubMed).
: "A role for the scaffolding adapter GAB2 in breast cancer." in: Nature medicine, Vol. 12, Issue 1, pp. 114-21, (2006) (PubMed).
: "From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 6, pp. 1072-81, (2006) (PubMed).
: "Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules." in: The Journal of biological chemistry, Vol. 276, Issue 48, pp. 45175-83, (2001) (PubMed).
Synonyms and alternative names related to GAB2
GRB2 associated binding protein 2 (GAB2), GRB2 associated binding protein 2 (gab2), GRB2-associated binding protein 2 (Gab2), growth factor receptor bound protein 2-associated protein 2 (Gab2), AI463667, D130058I17Rik, GAB2, p97Protein level used designations for GAB2
- GRB2-associated binding protein 2
- GRB2-associated-binding protein 2
- Grb2-associated binder 2
- growth factor receptor bound protein 2-associated protein 2
- pp100
- GRB2-associated binder 2
- Grb2 associated binder 2
- PH domain-containing adaptor molecule p97
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