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FZR1 抗体

(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
FZR1 抗体  (AA 1-493) FZR1 抗体  (AA 1-493) FZR1 抗体 (AA 1-493) (ABIN526652)

FZR1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 4C4 unconjugated

FZR1 抗体  (N-Term) FZR1 抗体  (N-Term) FZR1 抗体 (N-Term) (ABIN2784494)

FZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

FZR1 抗体  (AA 141-240) FZR1 抗体  (AA 141-240) FZR1 抗体 (AA 141-240) (ABIN1714172)

FZR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

FZR1 抗体 by 适用

Find FZR1 抗体 for a variety of species such as anti-Human FZR1, anti-Mouse FZR1, anti-Rat FZR1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find FZR1 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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FZR1 抗体 by 抗原表位

Find FZR1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

FZR1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal FZR1 抗体. Click on a link to go to the corresponding products.

FZR1 抗体 by 克隆

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FZR1 抗体 by 标记

Find FZR1 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular FZR1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), PLA
Validations
  • (5)
Cat. No. ABIN526652
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (1)
  • (5)
Cat. No. ABIN2784494
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (3)
Cat. No. ABIN1714172
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN526653
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN790512
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7152956
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6140852
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6243204
Quantity 200 μL
Datasheet Datasheet
Reactivity Bat, Human, Monkey, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6746327
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6744910
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN928538
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (2)
Cat. No. ABIN2773984
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IP
Validations
  • (2)
Cat. No. ABIN487309
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN1700670
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
Cat. No. ABIN4909759
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our FZR1 抗体

Li, Zhang, Yao, Zhang, Wan, Zhang: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." in: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).

Kim, Cho, Wang, Park, Ma, Kim, Gan, Jho, Cha, Jeung, Zhang, Gao, Wei, Jiang, Chung, Yang: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).

Yang, Jin, Fan, Liang, Jia, Tan, Huang, Li, Ma, Li: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." in: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).

Giráldez, Galindo-Moreno, Limón-Mortés, Rivas, Herrero-Ruiz, Mora-Santos, Sáez, Japón, Tortolero, Romero: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).

Fuchsberger, Martínez-Bellver, Giraldo, Teruel-Martí, Lloret, Viña: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." in: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).

Hu, Li, Li, Tan, Wan, Zhu, Zhang, Zhang, Yao: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).

Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." in: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).

Aliases for FZR1 抗体

fizzy and cell division cycle 20 related 1 (Fzr1) 抗体
fizzy/cell division cycle 20 related 1 (CDH1-C) 抗体
fizzy and cell division cycle 20 related 1 (FZR1) 抗体
fizzy-related protein homolog (LOC100027495) 抗体
fizzy-related protein homolog (LOC100179951) 抗体
fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1) 抗体
fizzy/cell division cycle 20 related 1a (fzr1a) 抗体
AW108046 抗体
CDC20C 抗体
CDH1 抗体
Cdh1 抗体
CDH1-C 抗体
FYR 抗体
Fyr 抗体
FZR 抗体
fzr1 抗体
FZR2 抗体
HCDH 抗体
HCDH1 抗体
zgc:55450 抗体
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