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FYB 产品

(FYN-Binding Protein (FYB))
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

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Featured FYB Categories

FYB 抗体

High quality antibodies with extensive validation data.

FYB ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FYB 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FYB 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, ICC, IF, IHC
Validations
  • (3)
Cat. No. ABIN6261835
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN3184706
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN7267283
Quantity 100 μL
Datasheet Datasheet

Recommended FYB ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1133831
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1133832
Quantity 96 tests
Datasheet Datasheet

Recommended FYB 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2721484
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2721483
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our FYB Products

Lettau, Kliche, Kabelitz, Janssen: "The adapter proteins ADAP and Nck cooperate in T cell adhesion." in: Molecular immunology, Vol. 60, Issue 1, pp. 72-9, (2014) (PubMed).

Medeiros, Burbach, Mueller, Srivastava, Moon, Highfill, Peterson, Shimizu: "Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1." in: Science (New York, N.Y.), Vol. 316, Issue 5825, pp. 754-8, (2007) (PubMed).

Mueller, Thomas, Burbach, Peterson, Shimizu: "Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 6, pp. 3559-69, (2007) (PubMed).

Rawlings, Sommer, Moreno-García: "The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes." in: Nature reviews. Immunology, Vol. 6, Issue 11, pp. 799-812, (2006) (PubMed).

Geng, Pfister, Kraeft, Rudd: "Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11527-32, (2001) (PubMed).

Griffiths, Krawczyk, Kong, Raab, Hyduk, Bouchard, Chan, Kozieradzki, Oliveira-Dos-Santos, Wakeham, Ohashi, Cybulsky, Rudd, Penninger: "Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap." in: Science (New York, N.Y.), Vol. 293, Issue 5538, pp. 2260-3, (2001) (PubMed).

Synonyms and alternative names related to FYB

FYN-binding protein (fyb), FYN binding protein 1 (FYB1), FYN binding protein (Fyb), FYN binding protein 1 (Fyb1), ADAP, B630013F22Rik, fyb, FYB-120/130, p120/130, p120/p130, PRO0823, RGD1563421, SLAP-130, Slap130

Protein level used designations for FYB

  • FYN-binding protein
  • FYB-120/130
  • FYN-T-binding protein
  • SLP-76-associated phosphoprotein
  • adhesion and degranulation-promoting adaptor protein
  • p120/p130
  • FYN binding protein FYB-130
  • adhesion and degranulation promoting adaptor protein
  • FYN binding protein (FYB-120/130)
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