FOXP2 产品
(Forkhead Box P2 (FOXP2))
Categories
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
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Featured FOXP2 Categories
Recommended FOXP2 抗体
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Reactivity
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Datasheet
Reactivity
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Cat. No.
ABIN263146
Quantity
100 μg
Datasheet
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Reactivity
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Cat. No.
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Recommended FOXP2 ELISA试剂盒
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Reactivity
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Cat. No.
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Quantity
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Recommended FOXP2 蛋白
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ABIN1354389
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Reactivity
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Source
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Cat. No.
ABIN1354391
Quantity
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Datasheet
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Reactivity
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Source
Escherichia coli (E. coli)
Validations
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ABIN7422919
Quantity
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Datasheet
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Latest Publications for our FOXP2 Products
: "Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth." in: eLife, Vol. 8, (2020) (PubMed).: "Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration." in: Scientific reports, Vol. 7, Issue 1, pp. 10220, (2019) (PubMed).
: "Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum." in: The Journal of comparative neurology, Vol. 525, Issue 14, pp. 2971-2990, (2018) (PubMed).
: "Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms." in: eLife, Vol. 6, (2017) (PubMed).
: "Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 17, pp. 6667-88, (2015) (PubMed).
: "Developmental Markers Expressed in Neocortical Layers Are Differentially Exhibited in Olfactory Cortex." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138541, (2015) (PubMed).
: "MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis." in: Cell stem cell, Vol. 15, Issue 6, pp. 762-74, (2014) (PubMed).
: "Expression of Kv1.3 potassium channels regulates density of cortical interneurons." in: Developmental neurobiology, Vol. 73, Issue 11, pp. 841-55, (2013) (PubMed).
: "Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 45, pp. 15688-703, (2012) (PubMed).
: "ATR maintains select progenitors during nervous system development." in: The EMBO journal, Vol. 31, Issue 5, pp. 1177-89, (2012) (PubMed).
Synonyms and alternative names related to FOXP2
forkhead box P2 (FOXP2), forkhead box P2 (Foxp2), forkhead box P2 (foxp2), forkhead box P2 (foxP2), lmw-gs (Foxp2), forkhead box transcription factor (foxp1c), forkhead box P2 L homeolog (foxp2.L), 2810043D05Rik, AI449000, CAG-16, CAGH44, cagh44, D0Kist7, foxP, FOXP2, foxP2, Foxp2, foxp2a, foxP2b, RGD1559697, SPCH1, spch1, TNRC10, tnrc10, xlFoxP2Protein level used designations for FOXP2
- CAG repeat protein 44
- forkhead box protein P2
- forkhead/winged-helix transcription factor
- trinucleotide repeat containing 10
- trinucleotide repeat-containing gene 10 protein
- forkhead box P2
- transcription factor FoxP2
- forkhead box P protein
- lmw-gs
- forkhead box transcription factor
- xlFoxP2
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