FMO3 产品
(Flavin Containing Monooxygenase 3 (FMO3))
Categories
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009].
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Featured FMO3 Categories
Recommended FMO3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN7267216
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN515768
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN2855649
Quantity
100 μL
Datasheet
Datasheet
Recommended FMO3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354250
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7423360
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2721250
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our FMO3 Products
: "Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 19, Issue 9, pp. 1213-20, (2006) (PubMed).: "Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 30, Issue 10, pp. 1043-52, (2002) (PubMed).
Synonyms and alternative names related to FMO3
flavin containing monooxygenase 3 (FMO3), flavin containing monooxygenase 3 (fmo3), flavin containing monooxygenase 3 L homeolog (fmo3.L), flavin containing monooxygenase 3 (Fmo3), AW111792, dJ127D3.1, FM03, FMOII, MGC107820, TMAUProtein level used designations for FMO3
- dimethylaniline monooxygenase [N-oxide-forming] 3
- flavin containing monooxygenase 3
- FMO 3
- FMO II
- FMO form 2
- dimethylaniline oxidase 3
- hepatic flavin-containing monooxygenase 3
- hepatic flavin-containing monooxygenase-3
- trimethylamine monooxygenase
- flavin-containing monooxygenase 3
- FMO 1D1
- flavin-containing monooxygenase FMO3
- flavin-containing monooxygenase form 3
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