FK506 Binding Protein 1A, 12kDa 产品
(FK506 Binding Protein 1A, 12kDa (FKBP1A))
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].
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Featured FK506 Binding Protein 1A, 12kDa Categories
FK506 Binding Protein 1A, 12kDa 抗体
High quality antibodies with extensive validation data.
FK506 Binding Protein 1A, 12kDa ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FK506 Binding Protein 1A, 12kDa 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FK506 Binding Protein 1A, 12kDa 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN1882082
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (4)
Cat. No.
ABIN560904
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN3022504
Quantity
100 μL
Datasheet
Datasheet
Recommended FK506 Binding Protein 1A, 12kDa ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955918
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955919
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951130
Quantity
96 tests
Datasheet
Datasheet
Recommended FK506 Binding Protein 1A, 12kDa 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (3)
- (1)
Cat. No.
ABIN1354116
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122973
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122972
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FK506 Binding Protein 1A, 12kDa Products
: "Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics." in: Biochemical and biophysical research communications, Vol. 422, Issue 4, pp. 732-8, (2012) (PubMed).: "Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 154, Issue 3, pp. 306-13, (2011) (PubMed).
: "Protein-protein interactions: an application of Tus-Ter mediated protein microarray system." in: Methods in molecular biology (Clifton, N.J.), Vol. 723, pp. 185-200, (2011) (PubMed).
: "Coupling surface plasmon resonance to mass spectrometry to discover novel protein-protein interactions." in: Nature protocols, Vol. 4, Issue 7, pp. 1023-37, (2009) (PubMed).
: "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T." in: Journal of neurochemistry, Vol. 106, Issue 1, pp. 121-33, (2008) (PubMed).
: "A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis." in: Cancer research, Vol. 68, Issue 8, pp. 2934-43, (2008) (PubMed).
: "Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins." in: Journal of proteome research, Vol. 6, Issue 10, pp. 3952-61, (2007) (PubMed).
: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).
: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).
: "Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A." in: Nature, Vol. 352, Issue 6338, pp. 803-7, (1991) (PubMed).
Synonyms and alternative names related to FK506 Binding Protein 1A, 12kDa
FK506 binding protein 1a (Fkbp1a), FK506 binding protein 1A (FKBP1A), FK506-binding protein (Fkbp12), FK506-binding protein 12 (FKBP12), FK506 binding protein 1Aa (fkbp1aa), FK506 binding protein 1C (FKBP1C), FK506-binding protein (EHI_180160), FK506-binding protein 59 (LOC5573443), FK506-binding protein (Fkbp13), FK506 binding protein like (FKBPL), FK506 binding protein 1A L homeolog (fkbp1a.L), FK506 binding protein 1A (Fkbp1a), FK506 binding protein 1Ab (fkbp1ab), 12kDa, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12, ATFKBP12, Bmfkbp13, fj02g10, FK506-binding protein 12, Fkbp, FKBP-1A, FKBP-12, Fkbp1, FKBP1, FKBP1A, FKBP1B, Fkbp2, FKBP12, Fkbp12, FKBP12-T1, FKBP12-T2, IMMUNOPHILIN, mFKBP1, mFKBP12, MSJ1.19, MSJ1_19, PKC12, PKCI2, PPIASE, Rotamase, wu:fj02g10, zgc:73373, zgc:103752Protein level used designations for FK506 Binding Protein 1A, 12kDa
- 12 kDa FK506-binding protein
- 12 kDa FKBP
- FK506 Binding Protein12-T1
- FK506 binding protein12
- FK506 binding protein12-T2
- FK506-binding protein 1A
- FKBP-12
- FKBP-1A
- FKBP12-Exip3
- PPIase FKBP1A
- calstabin-1
- immunophilin FKBP12
- peptidyl-prolyl cis-trans isomerase FKBP1A
- rotamase
- Immunophilin FKBP12
- binding protein
- FK506-binding protein
- FK506-binding protein 1
- FK506-binding protein 12
- FK506-binding protein 1A (12kD)
- FK506-binding protein, T-cell, 12-kD
- calstabin 1
- protein kinase C inhibitor 2
- FK506 binding protein 1B, 12.6 kDa
- FK506 binding protein 2 (13 kDa)
- FK506-binding protein 1 (12kD)
- FK506-binding protein 1a
- FK506 binding protein 1A, 12kDa
- fk506-binding protein
- FK506-binding protein-like
- FK 506-binding protein
- FK506 binding protein 1-like
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