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FIP1L1 蛋白

(FIP1 Like 1 (FIP1L1))

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

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FIP1L1 Protein (AA 1-378) (GST tag) (ABIN1354102)

FIP1L1 宿主: 人宿主: 小麦胚 Recombinant AA, AP, ELISA, WB

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FIP1L1 蛋白 by Origin

Find FIP1L1 蛋白 for a variety of species such as anti-Human FIP1L1. The species listed below are among those available. Click on a link to go to the corresponding products.

FIP1L1 蛋白 by Source

Here you will find FIP1L1 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

FIP1L1 蛋白 by 蛋白类型

Here you can find FIP1L1 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

FIP1L1 蛋白 by 应用范围

Find FIP1L1 蛋白 validated for a specific application such as AP, AA, ELISA, WB. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular FIP1L1 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

FIP1L1 Protein (AA 1-378) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1354102

Quantity 10 μg

Datasheet Datasheet

Aliases for FIP1L1 蛋白

factor interacting with PAPOLA and CPSF1 (fip1l1) 蛋白
factor interacting with PAPOLA and CPSF1 (FIP1L1) 蛋白
factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S) 蛋白
factor interacting with PAPOLA and CPSF1 (Fip1l1) 蛋白
FIP1 like 1 (S. cerevisiae) (Fip1l1) 蛋白
FIP1 like 1b (S. cerevisiae) (fip1l1b) 蛋白
1300019H17Rik 蛋白
FIP1 蛋白
fip1l1 蛋白
hFip1 蛋白
Rhe 蛋白
Rje 蛋白
wu:fd36f11 蛋白
zgc:103421 蛋白

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