FIP1L1 产品
(FIP1 Like 1 (FIP1L1))
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This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
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Featured FIP1L1 Categories
Recommended FIP1L1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7263123
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6140640
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN529371
Quantity
100 μg
Datasheet
Datasheet
Recommended FIP1L1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228423
Quantity
96 tests
Datasheet
Datasheet
Recommended FIP1L1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354102
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our FIP1L1 Products
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).Synonyms and alternative names related to FIP1L1
factor interacting with PAPOLA and CPSF1 (fip1l1), factor interacting with PAPOLA and CPSF1 (FIP1L1), factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S), factor interacting with PAPOLA and CPSF1 (Fip1l1), FIP1 like 1 (S. cerevisiae) (Fip1l1), FIP1 like 1b (S. cerevisiae) (fip1l1b), 1300019H17Rik, FIP1, fip1l1, hFip1, Rhe, Rje, wu:fd36f11, zgc:103421Protein level used designations for FIP1L1
- FIP1 like 1
- FIP1-like 1 protein
- pre-mRNA 3'-end-processing factor FIP1
- FIP1L1 cleavage and polyadenylation specific factor subunit
- factor interacting with PAP
- rearranged in hypereosinophilia
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