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FHL1 产品

(Four and A Half LIM Domains 1 (FHL1))

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This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009].

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Featured FHL1 Categories

FHL1 抗体

High quality antibodies with extensive validation data.

FHL1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FHL1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FHL1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (6)
Cat. No. ABIN560899
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IC
Validations
  • (2)
  • (1)
Cat. No. ABIN7306298
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
Application WB, IHC
Validations
  • (12)
  • (4)
Cat. No. ABIN2775759
Quantity 100 μL
Datasheet Datasheet

Recommended FHL1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955987
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1133659
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1133660
Quantity 96 tests
Datasheet Datasheet

Recommended FHL1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354072
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354074
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2721133
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our FHL1 Products

Meertens, Hafirassou, Couderc, Bonnet-Madin, Kril, Kümmerer, Labeau, Brugier, Simon-Loriere, Burlaud-Gaillard, Doyen, Pezzi, Goupil, Rafasse, Vidalain, Bertrand-Legout, Gueneau, Juntas-Morales et al.: "FHL1 is a major host factor for chikungunya virus infection. ..." in: Nature, Vol. 574, Issue 7777, pp. 259-263, (2019) (PubMed).

Le Thanh, Meinke, Korfali, Srsen, Robson, Wehnert, Schoser, Sewry, Schirmer: "Immunohistochemistry on a panel of Emery-Dreifuss muscular dystrophy samples reveals nuclear envelope proteins as inconsistent markers for pathology." in: Neuromuscular disorders : NMD, Vol. 27, Issue 4, pp. 338-351, (2017) (PubMed).

Xue, Schoser, Rao, Quadrelli, Vaglio, Rupp, Beichler, Nelson, Schapacher-Tilp, Windpassinger, Wilcox: "Exome Sequencing Identified a Splice Site Mutation in FHL1 that Causes Uruguay Syndrome, an X-Linked Disorder With Skeletal Muscle Hypertrophy and Premature Cardiac Death." in: Circulation. Cardiovascular genetics, Vol. 9, Issue 2, pp. 130-5, (2016) (PubMed).

Emmanuele, Kubota, Garcia-Diaz, Garone, Akman, Sánchez-Gutiérrez, Escudero, Kariya, Homma, Tanji, Quinzii, Hirano: "Fhl1 W122S causes loss of protein function and late-onset mild myopathy." in: Human molecular genetics, Vol. 24, Issue 3, pp. 714-26, (2015) (PubMed).

Albrecht, Wick, Hallgren, Tjärnlund, Nagaraju, Andrade, Thompson, Coley, Phadke, Diaz-Gallo, Bottai, Nennesmo, Chemin, Herrath, Johansson, Wikberg, Ytterberg, Zubarev, Danielsson, Krystufkova et al.: "Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. ..." in: The Journal of clinical investigation, Vol. 125, Issue 12, pp. 4612-24, (2015) (PubMed).

Ma, Mao, Shen, Zheng, Li, Liu, Ni: "Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits." in: Biochemical and biophysical research communications, Vol. 450, Issue 1, pp. 353-9, (2014) (PubMed).

Zhang, Chen, Sharma, Moon, Sheftel, Dawood, Nghiem, Wu, Li, Gramolini, Sorensen, Penninger, Brumell, Liu: "HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress." in: Nature communications, Vol. 5, pp. 3430, (2014) (PubMed).

Fujii, Hayashi, Kawamura, Higuchi, Tsugawa, Ohyagi, Hayashi, Nishino, Kira: "A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles." in: Journal of the neurological sciences, Vol. 343, Issue 1-2, pp. 206-10, (2014) (PubMed).

Koike, Kasamatsu, Iyoda, Saito, Kouzu, Koike, Sakamoto, Ogawara, Tanzawa, Uzawa: "High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer." in: International journal of oncology, Vol. 42, Issue 1, pp. 141-50, (2012) (PubMed).

Sharma, Shathasivam, Ignatchenko, Kislinger, Gramolini: "Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis." in: Molecular bioSystems, Vol. 7, Issue 4, pp. 1185-96, (2011) (PubMed).

Synonyms and alternative names related to FHL1

four and a half LIM domains 1 (fhl1), four and a half LIM domains 1 (FHL1), four and a half LIM domains 1a (fhl1a), Four and a half LIM domains protein 1 (fhl1), four and a half LIM domains 1 S homeolog (fhl1.S), four and a half LIM domains 1 (Fhl1), DKFZp468O1927, fhl, FHL-1, fhl1, FHL1, Fhl1, FHL1A, FHL1B, fhla, FLH1A, KYOT, KyoT, MGC89165, SLIM, SLIM-1, SLIM1, SLIMMER, XMPMA, zgc:92025

Protein level used designations for FHL1

  • four and a half LIM domains 1
  • four and a half LIM domains protein 1-like
  • four and a half LIM domains a
  • four and a half LIM domains protein 1
  • Four and a half LIM domains protein 1
  • four and a half lim domains protein 1
  • LIM protein SLIMMER
  • four-and-a-half Lin11, Isl-1 and Mec-3 domains 1
  • skeletal muscle LIM-protein 1
  • FHL-1
  • RAM14-1
  • RBP-associated molecule 14-1
  • SLIM
  • SLIM-1
  • four and a half LIM domains 1 protein
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