Fgr 产品
(Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
Categories
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
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Featured Fgr Categories
Fgr 抗体
High quality antibodies with extensive validation data.
Fgr ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Fgr 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Fgr 抗体
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Reactivity
Application
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Reactivity
Human
Application
WB, ELISA, IHC (p)
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- (6)
Cat. No.
ABIN560883
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (2)
- (5)
Cat. No.
ABIN392096
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
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- (3)
Cat. No.
ABIN7174020
Quantity
100 μg
Datasheet
Datasheet
Recommended Fgr ELISA试剂盒
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Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4886105
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385940
Quantity
96 tests
Datasheet
Datasheet
Reactivity
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Analytical Method
Quantitative Sandwich ELISA
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ABIN4882882
Quantity
96 tests
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Recommended Fgr 蛋白
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Reactivity
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Source
Wheat germ
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Cat. No.
ABIN1354064
Quantity
10 μg
Datasheet
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Reactivity
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Source
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Cat. No.
ABIN1354066
Quantity
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Datasheet
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Reactivity
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Source
HEK-293 Cells
Validations
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Cat. No.
ABIN2721125
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Datasheet
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Latest Publications for our Fgr Products
: "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells." in: eLife, Vol. 8, (2020) (PubMed).: "Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 163-75, (2016) (PubMed).
: "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages." in: eLife, Vol. 4, (2016) (PubMed).
: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).
: "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 10, pp. 3540-9, (2009) (PubMed).
: "Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor." in: Biochemistry, Vol. 46, Issue 39, pp. 11023-32, (2007) (PubMed).
: "The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B." in: Immunity, Vol. 22, Issue 2, pp. 235-46, (2005) (PubMed).
: "Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions." in: Biological chemistry, Vol. 383, Issue 1, pp. 107-13, (2002) (PubMed).
: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, (1994) (PubMed).
: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, (1994) (PubMed).
Synonyms and alternative names related to Fgr
FGR proto-oncogene, Src family tyrosine kinase (FGR), FGR proto-oncogene, Src family tyrosine kinase (Fgr), c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, SRC2Protein level used designations for Fgr
- Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
- c-fgr protooncogene
- c-src-2 proto-oncogene
- p55-c-fgr protein
- proto-oncogene c-Fgr
- proto-oncogene tyrosine-protein kinase FGR
- tyrosine-protein kinase Fgr
- v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
- Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
- proto-oncogene tyrosine-protein kinase Fgr
- tyrosine-protein kinase Fgr-like
- p55-Fgr
- feline Gardner-Rasheed sarcoma viral oncogene homolog
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