FEN1 抗体
(Flap Structure-Specific Endonuclease 1 (FEN1))
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Latest Publications for our FEN1 抗体
: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." in: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." in: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).
: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." in: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).
: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." in: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).
: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).
: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." in: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).
: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." in: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).
: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." in: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).
Aliases for FEN1 抗体
flap structure-specific endonuclease 1 (FEN1) 抗体flap endonuclease 1-like (LOC100808044) 抗体
Flap endonuclease-1 (Bm1_49605) 抗体
5'-3' exonuclease family protein (AT5G26680) 抗体
flap structure specific endonuclease 1 (Fen1) 抗体
flap structure-specific endonuclease 1 (fen1) 抗体
flap structure-specific endonuclease 1 L homeolog (fen1.L) 抗体
flap structure-specific endonuclease 1 (Fen1) 抗体
nuclease, Rad2 family (FEN1) 抗体
AW538437 抗体
cb879 抗体
FEN-1 抗体
fen-1 抗体
FEN1 抗体
fen1 抗体
MF1 抗体
mf1 抗体
RAD2 抗体
rad2 抗体
xFEN1a 抗体
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