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FEN1 抗体

(Flap Structure-Specific Endonuclease 1 (FEN1))
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
FEN1 抗体  (AA 50-380) FEN1 抗体  (AA 50-380) FEN1 抗体 (AA 50-380) (ABIN3021632)

FEN1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

FEN1 抗体 FEN1 抗体 FEN1 抗体 (ABIN2855166)

FEN1 适用: 人 WB, IHC, IF, IP, IHC (p), ICC, PLA 宿主: 兔 Polyclonal unconjugated

FEN1 抗体 FEN1 抗体 FEN1 抗体 (ABIN7255764)

FEN1 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

FEN1 抗体 by Grade

Find FEN1 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

FEN1 抗体 by 适用

Find FEN1 抗体 for a variety of species such as anti-Human FEN1, anti-Mouse FEN1, anti-Rat FEN1. The species listed below are among those available. Click on a link to go to the corresponding products.

FEN1 抗体 by 应用范围

Find FEN1 抗体 validated for a specific application such as WB, IF, IHC, IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

FEN1 抗体 by 抗体来源

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FEN1 抗体 by 抗原表位

Find FEN1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

FEN1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal FEN1 抗体. Click on a link to go to the corresponding products.

FEN1 抗体 by 克隆

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FEN1 抗体 by 标记

Find FEN1 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular FEN1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (6)
Cat. No. ABIN3021632
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IP, IHC (p), ICC, PLA
Validations
  • (6)
Cat. No. ABIN2855166
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN7255764
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (3)
Cat. No. ABIN7127487
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN515596
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (4)
  • (3)
Cat. No. ABIN1944939
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7186701
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IP
Validations
  • (2)
Cat. No. ABIN6241658
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ICC
Validations
  • (2)
Cat. No. ABIN6241657
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF
Validations
  • (2)
Cat. No. ABIN3184606
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN515598
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN7267215
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN389376
Quantity 400 μL
Datasheet Datasheet

Application WB
Validations
  • (3)
Cat. No. ABIN2782482
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, IHC, IF, IP, IC
Validations
  • (3)
Cat. No. ABIN7295650
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our FEN1 抗体

Moreli, Santos, Lorenzon-Ojea, Corrêa-Silva, Fortunato, Rocha, Rudge, Damasceno, Bevilacqua, Calderon: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." in: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).

Duxin, Moore, Sidorova, Karanja, Honaker, Dao, Piwnica-Worms, Campbell, Monnat, Stewart: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." in: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).

Jaiswal, Armas, Izumi, Strauss, Narayan: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." in: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).

Ma, Liang, Liu, Axcrona, Kvalheim, Stokke, Nesland, Suo: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." in: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).

Tann, Boldogh, Meiss, Qian, Van Houten, Mitra, Szczesny: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).

Jaiswal, Narayan: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." in: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).

Asagoshi, Liu, Masaoka, Lan, Prasad, Horton, Brown, Wang, Bdour, Sobol, Taylor, Yasui, Wilson: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).

Saharia, Teasley, Duxin, Dao, Chiappinelli, Stewart: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).

Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." in: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).

Sampathi, Bhusari, Shen, Chai: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." in: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).

Aliases for FEN1 抗体

flap structure-specific endonuclease 1 (FEN1) 抗体
flap endonuclease 1-like (LOC100808044) 抗体
Flap endonuclease-1 (Bm1_49605) 抗体
5'-3' exonuclease family protein (AT5G26680) 抗体
flap structure specific endonuclease 1 (Fen1) 抗体
flap structure-specific endonuclease 1 (fen1) 抗体
flap structure-specific endonuclease 1 L homeolog (fen1.L) 抗体
flap structure-specific endonuclease 1 (Fen1) 抗体
nuclease, Rad2 family (FEN1) 抗体
AW538437 抗体
cb879 抗体
FEN-1 抗体
fen-1 抗体
FEN1 抗体
fen1 抗体
MF1 抗体
mf1 抗体
RAD2 抗体
rad2 抗体
xFEN1a 抗体
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