FE65 抗体
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
recommended
recommended
APBB1 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
FE65 抗体 by Grade
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FE65 抗体 by 适用
Find FE65 抗体 for a variety of species such as anti-Mouse FE65, anti-Rat FE65, anti-Human FE65. The species listed below are among those available. Click on a link to go to the corresponding products.
FE65 抗体 by 应用范围
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FE65 抗体 by 抗体来源
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FE65 抗体 by 克隆形成能力
Find available monoclonal or polyclonal FE65 抗体. Click on a link to go to the corresponding products.
Popular FE65 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3043784
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
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Cat. No.
ABIN725075
Quantity
100 μL
Datasheet
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Application
ELISA, IHC
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Cat. No.
ABIN7144040
Quantity
100 μL
Datasheet
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Application
WB, IF
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Cat. No.
ABIN513387
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN6259972
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
- (1)
Cat. No.
ABIN755797
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN185689
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6746407
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
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Cat. No.
ABIN6136973
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
- (1)
Cat. No.
ABIN928785
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (2)
Cat. No.
ABIN2786224
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (2)
Cat. No.
ABIN3029930
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN755812
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN725077
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN755799
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our FE65 抗体
: "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development." in: The EMBO journal, Vol. 25, Issue 2, pp. 420-31, (2006) (PubMed).: "FE65 interaction with the ApoE receptor ApoEr2." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24521-30, (2006) (PubMed).
: "Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)." in: Molecular biology of the cell, Vol. 18, Issue 1, pp. 201-10, (2006) (PubMed).
: "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41182-8, (2003) (PubMed).
: "The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway." in: Biochemistry, Vol. 42, Issue 12, pp. 3627-34, (2003) (PubMed).
: "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." in: Biochemistry, Vol. 42, Issue 22, pp. 6664-73, (2003) (PubMed).
: "A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60." in: Science (New York, N.Y.), Vol. 293, Issue 5527, pp. 115-20, (2001) (PubMed).
Aliases for FE65 抗体
amyloid beta precursor protein binding family B member 1 (APBB1) 抗体amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog (apbb1.L) 抗体
amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1) 抗体
amyloid beta precursor protein binding family B member 1 (Apbb1) 抗体
apbb1 抗体
FE65 抗体
Fe65 抗体
MGC80654 抗体
MGC:9072 抗体
RIR 抗体
Rir 抗体
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