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FDPS 产品

(Farnesyl Diphosphate Synthase (FDPS))

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This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].

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Featured FDPS Categories

FDPS 抗体

High quality antibodies with extensive validation data.

FDPS ELISA试剂盒

Reliable ELISA kits for a wide range of species.

FDPS 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FDPS 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p), ICC, IF
Validations
  • (5)
Cat. No. ABIN2856081
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (4)
Cat. No. ABIN7152571
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7442606
Quantity 100 μL
Datasheet Datasheet

Recommended FDPS ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955697
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955696
Quantity 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method
Validations
Cat. No. ABIN1132991
Quantity 96 tests
Datasheet Datasheet

Recommended FDPS 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353936
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1353934
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7504326
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our FDPS Products

Chimenti, Camprubí-Rimblas, Guillamat-Prats, Gomez, Tijero, Blanch, Artigas: "Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury." in: Thrombosis and haemostasis, Vol. 117, Issue 11, pp. 2125-2134, (2018) (PubMed).

Sousa, Auriola, Mönkkönen, Määttä: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." in: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).

Todenhöfer, Hennenlotter, Kühs, Gerber, Gakis, Vogel, Aufderklamm, Merseburger, Knapp, Stenzl, Schwentner: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" in: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).

Miyazaki, Kato, Tanaka, Tanaka, Takao, Kohjima, Ito, Enjoji, Nakamuta, Kotoh, Takayanagi: "Antithrombin III injection via the portal vein suppresses liver damage." in: World journal of gastroenterology, Vol. 18, Issue 16, pp. 1884-91, (2012) (PubMed).

Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." in: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).

Räikkönen, Mönkkönen, Auriola, Mönkkönen: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." in: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).

Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Wilkin, Kutsunai, Edwards et al.: "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ..." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4607-14, (1990) (PubMed).

Synonyms and alternative names related to FDPS

Farnesyl pyrophosphate synthase (Fpps), farnesyl diphosphate synthase (fdps), farnesyl diphosphate synthase L homeolog (fdps.L), farnesyl pyrophosphate synthase (MGG_08649), farnesyl pyrophosphate synthetase (TP03_0857), farnesyl pyrophosphate synthetase (Tb09.160.4300), farnesyl-pyrophosphate synthetase (fpp), farnesyl pyrophosphate synthetase (BBOV_I000120), FDP synthase (fps), Farnesyl pyrophosphate synthetase (fpps), farnesyl diphosphate synthase (FDPS), farnesyl diphosphate synthase (Fdps), farnesyl diphosphate synthetase (Fdps), farnesyl pyrophosphate synthase 1 (fps1), (2E, 16.m00760, 6030492I17Rik, Ac2-125, AI256750, CG12389, DDBDRAFT_0206220, DDBDRAFT_0215017, DDB_0206220, DDB_0215017, Dmel\\CG12389, DmFPPS, DmFPPSase, DmFPS, Fdpsl1, fpps, FPPS, FPS, fps, l(2)k06103, mKIAA1293, NCU01175.1, v(2)k03514

Protein level used designations for FDPS

  • farnesyl pyrophosphate synthase
  • CG12389-PA
  • Fpps-PA
  • farnesyl diphosphate synthase
  • farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
  • farnesyl pyrophosphate synthetase
  • Farnesyl pyrophosphate synthetase
  • (2E,6E)-farnesyl diphosphate synthase
  • FPP synthase
  • FPP synthetase
  • dimethylallyltranstransferase
  • farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
  • geranyltranstransferase
  • CR 39
  • cholesterol-regulated 39 kDa protein
  • farnesyl diphosphate synthetase
  • testis-specific farnesyl pyrophosphate synthetase
  • FPS
  • 6E)-farnesyl diphosphate synthase
  • FPPS
  • GRMZM2G168681
  • PCO074380
  • PCO074380(592)
  • PCO074380_ov
  • PCO074380b
  • QBB18h08
  • geranylgeranyl-diphosphate synthase
  • gnp_QBB18h08b
  • gpm430b
  • prenyltransferase
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