FDPS 产品
(Farnesyl Diphosphate Synthase (FDPS))
Categories
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].
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Featured FDPS Categories
FDPS 抗体
High quality antibodies with extensive validation data.
FDPS ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FDPS 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FDPS 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), ICC, IF
Validations
- (5)
Cat. No.
ABIN2856081
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (4)
Cat. No.
ABIN7152571
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7442606
Quantity
100 μL
Datasheet
Datasheet
Recommended FDPS ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955697
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955696
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1132991
Quantity
96 tests
Datasheet
Datasheet
Recommended FDPS 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353936
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353934
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504326
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FDPS Products
: "Nebulized Heparin Attenuates Pulmonary Coagulopathy and Inflammation through Alveolar Macrophages in a Rat Model of Acute Lung Injury." in: Thrombosis and haemostasis, Vol. 117, Issue 11, pp. 2125-2134, (2018) (PubMed).: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." in: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).
: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" in: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).
: "Antithrombin III injection via the portal vein suppresses liver damage." in: World journal of gastroenterology, Vol. 18, Issue 16, pp. 1884-91, (2012) (PubMed).
: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).
: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." in: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).
: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." in: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).
: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, ..." in: The Journal of biological chemistry, Vol. 265, Issue 8, pp. 4607-14, (1990) (PubMed).
Synonyms and alternative names related to FDPS
Farnesyl pyrophosphate synthase (Fpps), farnesyl diphosphate synthase (fdps), farnesyl diphosphate synthase L homeolog (fdps.L), farnesyl pyrophosphate synthase (MGG_08649), farnesyl pyrophosphate synthetase (TP03_0857), farnesyl pyrophosphate synthetase (Tb09.160.4300), farnesyl-pyrophosphate synthetase (fpp), farnesyl pyrophosphate synthetase (BBOV_I000120), FDP synthase (fps), Farnesyl pyrophosphate synthetase (fpps), farnesyl diphosphate synthase (FDPS), farnesyl diphosphate synthase (Fdps), farnesyl diphosphate synthetase (Fdps), farnesyl pyrophosphate synthase 1 (fps1), (2E, 16.m00760, 6030492I17Rik, Ac2-125, AI256750, CG12389, DDBDRAFT_0206220, DDBDRAFT_0215017, DDB_0206220, DDB_0215017, Dmel\\CG12389, DmFPPS, DmFPPSase, DmFPS, Fdpsl1, fpps, FPPS, FPS, fps, l(2)k06103, mKIAA1293, NCU01175.1, v(2)k03514Protein level used designations for FDPS
- farnesyl pyrophosphate synthase
- CG12389-PA
- Fpps-PA
- farnesyl diphosphate synthase
- farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
- farnesyl pyrophosphate synthetase
- Farnesyl pyrophosphate synthetase
- (2E,6E)-farnesyl diphosphate synthase
- FPP synthase
- FPP synthetase
- dimethylallyltranstransferase
- farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
- geranyltranstransferase
- CR 39
- cholesterol-regulated 39 kDa protein
- farnesyl diphosphate synthetase
- testis-specific farnesyl pyrophosphate synthetase
- FPS
- 6E)-farnesyl diphosphate synthase
- FPPS
- GRMZM2G168681
- PCO074380
- PCO074380(592)
- PCO074380_ov
- PCO074380b
- QBB18h08
- geranylgeranyl-diphosphate synthase
- gnp_QBB18h08b
- gpm430b
- prenyltransferase
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