FBXO4 产品
(F-Box Protein 4 (FBXO4))
Categories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
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Featured FBXO4 Categories
FBXO4 抗体
High quality antibodies with extensive validation data.
FBXO4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FBXO4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXO4 抗体
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Reactivity
Application
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Datasheet
Reactivity
Human
Application
WB, ELISA, IP, IHC
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- (4)
Cat. No.
ABIN7152437
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN525677
Quantity
100 μL
Datasheet
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Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7152439
Quantity
100 μg
Datasheet
Datasheet
Recommended FBXO4 ELISA试剂盒
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Reactivity
Analytical Method
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Sheep
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Cat. No.
ABIN1774002
Quantity
96 tests
Datasheet
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Human
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Quantitative Competition ELISA
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Cat. No.
ABIN1743097
Quantity
96 tests
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Dog
Analytical Method
Validations
Cat. No.
ABIN1769106
Quantity
96 tests
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Recommended FBXO4 蛋白
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Reactivity
Source
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Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353823
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3079809
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3126035
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FBXO4 Products
: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).: "PinX1 localizes to telomeres and stabilizes TRF1 at mitosis." in: Molecular and cellular biology, Vol. 32, Issue 8, pp. 1387-95, (2012) (PubMed).
: "Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ" in: Oncogene, (2011) (PubMed).
: "Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability." in: Molecular and cellular biology, Vol. 28, Issue 23, pp. 7245-58, (2008) (PubMed).
: "Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer." in: Cancer cell, Vol. 14, Issue 1, pp. 68-78, (2008) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance." in: The Journal of biological chemistry, Vol. 281, Issue 2, pp. 759-68, (2006) (PubMed).
: "Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex." in: Molecular cell, Vol. 24, Issue 3, pp. 355-66, (2006) (PubMed).
: "The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4699-704, (2003) (PubMed).
: "Induction of B cell costimulatory function by recombinant murine CD40 ligand." in: European journal of immunology, Vol. 24, Issue 1, pp. 116-23, (1994) (PubMed).
Synonyms and alternative names related to FBXO4
F-box protein 4 (FBXO4), F-box protein 4 (Fbxo4), F-box protein 4 (fbxo4), F-box protein 4 L homeolog (fbxo4.L), 1700096C12Rik, AI851261, AW494535, FBX4, Fbx4, fbx4, FBXO4, si:dkey-46a10.2Protein level used designations for FBXO4
- F-box only protein 4
- F-box protein Fbx4
- F-box protein 4
- F-box only protein 4-like
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