FBXO32 产品
(F-Box Protein 32 (FBXO32))
Categories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
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Featured FBXO32 Categories
FBXO32 抗体
High quality antibodies with extensive validation data.
FBXO32 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
FBXO32 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXO32 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (5)
Cat. No.
ABIN3017562
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7251817
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (1)
Cat. No.
ABIN747698
Quantity
100 μL
Datasheet
Datasheet
Recommended FBXO32 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966624
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966625
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966626
Quantity
96 tests
Datasheet
Datasheet
Recommended FBXO32 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1353808
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408129
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3128198
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FBXO32 Products
: "FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation." in: Oncogene, Vol. 36, Issue 23, pp. 3312-3321, (2017) (PubMed).: "Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 11, pp. 1967-1978, (2016) (PubMed).
: "Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting." in: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 11, pp. 1936-49, (2011) (PubMed).
: "The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3940-51, (2007) (PubMed).
Synonyms and alternative names related to FBXO32
F-box protein 32 (fbxo32), F-box protein 32 (FBXO32), F-box protein 32 (Fbxo32), 4833442G10Rik, AI430017, ATROGIN1, Atrogin1, Fbx32, Gm20361, MAFbx, MGC56479, zgc:56479Protein level used designations for FBXO32
- F-box only protein 32
- atrogin-1
- F-box protein 32
- F-box only protein 32-like
- atrogin 1
- muscle atrophy F-box protein
- atrophy gene 1
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