FAT1 抗体
(FAT Tumor Suppressor Homolog 1 (FAT1))
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008].
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FAT1 抗体
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Latest Publications for our FAT1 Products
: "A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding." in: PLoS ONE, Vol. 9, Issue 3, pp. e90461, (2014) (PubMed).: "Quantitative temporal viromics: an approach to investigate host-pathogen interaction." in: Cell, Vol. 157, Issue 6, pp. 1460-72, (2014) (PubMed).
: "The genomic landscape of nasopharyngeal carcinoma." in: Nature genetics, Vol. 46, Issue 8, pp. 866-71, (2014) (PubMed).
: "Genomic and molecular characterization of esophageal squamous cell carcinoma." in: Nature genetics, Vol. 46, Issue 5, pp. 467-73, (2014) (PubMed).
: "Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation." in: Nature genetics, Vol. 45, Issue 3, pp. 253-61, (2013) (PubMed).
: "Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy." in: PLoS genetics, Vol. 9, Issue 6, pp. e1003550, (2013) (PubMed).
Synonyms and alternative names related to FAT1
FAT atypical cadherin 1 (FAT1), FAT atypical cadherin 1 (Fat1), FAT tumor suppressor homolog 1 (Drosophila) (FAT1), protocadherin Fat 1 (LOC100175143), FAT atypical cadherin 1 (fat1), 2310038E12Rik, AU023433, CDHF7, CDHR8, FAT, FAT1, Fath, hFat1, ME5, mFat1Protein level used designations for FAT1
- FAT tumor suppressor 1
- FAT tumor suppressor homolog 1
- cadherin ME5
- cadherin family member 7
- cadherin-related family member 8
- cadherin-related tumor suppressor homolog
- protein fat homolog
- protocadherin Fat 1
- fat 1 cadherin
- FAT tumor suppressor homolog 1 (Drosophila)
- fat1-like
- protocadherin Fat 1-like
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