EXOSC10 产品
(Exosome Component 10 (EXOSC10))
Categories
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA (By similarity).
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Featured EXOSC10 Categories
EXOSC10 抗体
High quality antibodies with extensive validation data.
EXOSC10 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EXOSC10 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (1)
- (3)
Cat. No.
ABIN2778684
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (2)
Cat. No.
ABIN1714746
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN518993
Quantity
100 μg
Datasheet
Datasheet
Recommended EXOSC10 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6226645
Quantity
96 tests
Datasheet
Datasheet
Recommended EXOSC10 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353233
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353232
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134522
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our EXOSC10 Products
: "An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression." in: Genes & development, (2017) (PubMed).: "Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis." in: Cell reports, Vol. 13, Issue 8, pp. 1610-22, (2015) (PubMed).
: "RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells." in: eLife, Vol. 3, pp. e02112, (2014) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage." in: Genes & development, Vol. 27, Issue 20, pp. 2227-32, (2013) (PubMed).
: "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways." in: RNA (New York, N.Y.), Vol. 13, Issue 7, pp. 1027-35, (2007) (PubMed).
Synonyms and alternative names related to EXOSC10
exosome component 10 (exosc10), exosome component 10 (EXOSC10), exosome component 10 (EHI_021400), exosome component 10 (BBOV_IV002650), exosome component 10 (CpipJ_CPIJ003896), exosome component 10 (CMU_031760), 3'-5' exonuclease (exosc10), exosome component 10 (Tsp_05247), exosome component 10 L homeolog (exosc10.L), exosome component 10 (Exosc10), 21.m02990, 201.t00018, DDBDRAFT_0203581, DDBDRAFT_0233752, DDB_0203581, DDB_0233752, EXOSC10, p2, p3, p4, pm-scl, PM-Scl, pm/scl-100, PM/Scl-100, pmscl, PMSCL, Pmscl2, pmscl2, PMSCL2, rrp6, RRP6, rrp6p, Rrp6p, zgc:55695Protein level used designations for EXOSC10
- exosome component 10
- Exosome component 10
- P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
- autoantigen PM-SCL
- autoantigen PM/Scl 2
- polymyositis/scleroderma autoantigen 100 kDa
- polymyositis/scleroderma autoantigen 2 (100kD)
- polymyositis/scleroderma autoantigen 2, 100kDa
- autoantigen PM/Scl 2 homolog
- polymyositis/scleroderma autoantigen 2 homolog
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