ERVW-1 产品
(Endogenous Retrovirus Group W, Member 1 (ERVW-1))
Categories
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
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Featured ERVW-1 Categories
Recommended ERVW-1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7171179
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7239491
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN635520
Quantity
100 μL
Datasheet
Datasheet
Recommended ERVW-1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1353105
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ERVW-1 Products
: "Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPAR?/RXR? in placentogenesis." in: Journal of cellular biochemistry, Vol. 113, Issue 7, pp. 2383-96, (2012) (PubMed).: "Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1." in: Immunology, Vol. 136, Issue 2, pp. 184-91, (2012) (PubMed).
: "Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo." in: Molecular human reproduction, Vol. 17, Issue 12, pp. 747-57, (2011) (PubMed).
: "Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes." in: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 11, pp. 1143-56, (2010) (PubMed).
: "Stimulation of syncytium formation in vitro in human trophoblast cells by galectin-1." in: Placenta, Vol. 31, Issue 9, pp. 825-32, (2010) (PubMed).
Synonyms and alternative names related to ERVW-1
endogenous retrovirus group W member 1, envelope (ERVW-1), ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENVProtein level used designations for ERVW-1
- HERV-7q envelope protein
- HERV-W Env glycoprotein
- HERV-W envelope protein
- HERV-W_7q21.2 provirus ancestral Env polyprotein
- HERV-W{7q21.1} provirus ancestral Env polyprotein
- HERV-tryptophan envelope protein
- endogenous retroviral family W, env(C7), member 1
- endogenous retrovirus group W member 1
- env-W
- envelope glycoprotein
- envelope polyprotein gPr73
- envelope protein
- enverin
- human endogenous retrovirus W envC7-1 envelope protein
- syncytin A
- syncytin-1
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