ERBB3 抗体
(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
recommended
recommended
ERBB3 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01467 unconjugated
recommended
ERBB3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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Popular ERBB3 抗体
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Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Reactivity
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Application
WB, IHC (p), FACS
Validations
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Cat. No.
ABIN391949
Quantity
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Datasheet
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Reactivity
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WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro)
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Application
WB, IHC, ELISA, IF, ICC
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Cat. No.
ABIN6261585
Quantity
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Application
WB, IHC, ELISA, FACS
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Cat. No.
ABIN3029524
Quantity
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Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
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WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro)
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Cat. No.
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
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Datasheet
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Datasheet
Datasheet
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Quantity
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Datasheet
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Latest Publications for our ERBB3 抗体
: "Soluble HER3 predicts survival in bladder cancer patients." in: Oncology letters, Vol. 15, Issue 2, pp. 1783-1788, (2018) (PubMed).: "Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients." in: BMC cancer, Vol. 17, Issue 1, pp. 841, (2018) (PubMed).
: "Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141381, (2015) (PubMed).
: "A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism." in: The Journal of biological chemistry, (2015) (PubMed).
: "Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma." in: PLoS ONE, Vol. 10, Issue 3, pp. e0122555, (2015) (PubMed).
: "Paracrine Effect of NRG1 and HGF Drives Resistance to MEK Inhibitors in Metastatic Uveal Melanoma." in: Cancer research, Vol. 75, Issue 13, pp. 2737-48, (2015) (PubMed).
: "High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer." in: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, Vol. 33, Issue 4, pp. 402-10, (2014) (PubMed).
: "The MAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6261-72, (2013) (PubMed).
: "Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking." in: The Journal of cell biology, Vol. 199, Issue 5, pp. 799-816, (2012) (PubMed).
: "HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice." in: Cancer gene therapy, Vol. 19, Issue 12, pp. 888-98, (2012) (PubMed).
Aliases for ERBB3 抗体
erb-b2 receptor tyrosine kinase 3 (ERBB3) 抗体v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) 抗体
erb-b2 receptor tyrosine kinase 3 (Erbb3) 抗体
c-erbB-3 抗体
c-erbB3 抗体
C76256 抗体
ErbB-3 抗体
Erbb-3 抗体
ERBB3 抗体
erbB3-S 抗体
Erbb3r 抗体
HER3 抗体
Her3 抗体
LCCS2 抗体
MDA-BF-1 抗体
nuc-ErbB3 抗体
p45-sErbB3 抗体
p85-sErbB3 抗体
p180-ErbB3 抗体
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