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ErbB2/Her2 产品

(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

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This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

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Featured ErbB2/Her2 Categories

ErbB2/Her2 抗体

High quality antibodies with extensive validation data.

ErbB2/Her2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ErbB2/Her2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ErbB2/Her2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7444448
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (7)
Cat. No. ABIN6254225
Quantity 600 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p), PLA
Validations
  • (7)
Cat. No. ABIN515370
Quantity 100 μg
Datasheet Datasheet

Recommended ErbB2/Her2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6730948
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6959063
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6973408
Quantity 96 tests
Datasheet Datasheet

Recommended ErbB2/Her2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274799
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274796
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274800
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ErbB2/Her2 Products

Farràs, Román, Camps, Miret, Martínez, Pujol, Casablancas, Cairó: "Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab." in: BMC molecular and cell biology, Vol. 21, Issue 1, pp. 2, (2020) (PubMed).

Murakami, Matsumoto, Kanamori: "Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system." in: Scientific reports, Vol. 9, Issue 1, pp. 671, (2020) (PubMed).

Hao, Yu, Bai, McBride, Huang: "Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex." in: PLoS ONE, Vol. 14, Issue 5, pp. e0216095, (2020) (PubMed).

Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

Helsen, Hammill, Lau, Mwawasi, Afsahi, Bezverbnaya, Newhook, Hayes, Aarts, Bojovic, Denisova, Kwiecien, Brain, Derocher, Milne, Nelson, Bramson: "The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity." in: Nature communications, Vol. 9, Issue 1, pp. 3049, (2019) (PubMed).

Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

Hussack, Raphael, Lowden, Henry: "Isolation and characterization of camelid single-domain antibodies against HER2." in: BMC research notes, Vol. 11, Issue 1, pp. 866, (2019) (PubMed).

Shinozaki, Hashimoto, Fukui, Uchiyama: "Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities." in: Scientific reports, Vol. 7, Issue 1, pp. 5794, (2019) (PubMed).

Wang, Forterre, Zhao, Frimannsson, Delcayre, Antes, Efron, Jeffrey, Pegram, Matin: "Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation." in: Molecular cancer therapeutics, Vol. 17, Issue 5, pp. 1133-1142, (2019) (PubMed).

Mortensen, Skovsgaard, Okholm, Scavenius, Dupont, Rosen, Enghild, Kjems, Gothelf: "Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins." in: Bioconjugate chemistry, Vol. 29, Issue 9, pp. 3016-3025, (2019) (PubMed).

Synonyms and alternative names related to ErbB2/Her2

erb-b2 receptor tyrosine kinase 2 (ERBB2), erb-b2 receptor tyrosine kinase 2 (Erbb2), erb-b2 receptor tyrosine kinase 2 (erbb2), c-erbB2, c-neu, CD340, erb2, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, NEU, Neu, NGL, TKR1, wu:fv70f10, zgc:63601

Protein level used designations for ErbB2/Her2

  • c-erb B2/neu protein
  • herstatin
  • metastatic lymph node gene 19 protein
  • neuro/glioblastoma derived oncogene homolog
  • neuroblastoma/glioblastoma derived oncogene homolog
  • p185erbB2
  • proto-oncogene Neu
  • proto-oncogene c-ErbB-2
  • receptor tyrosine-protein kinase erbB-2
  • tyrosine kinase-type cell surface receptor HER2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • Neu oncogene
  • avian erythroblastosis oncogene B 2
  • c-erbB-2
  • proto-oncogene NEU
  • erbB-2
  • Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
  • C-erbB-2
  • NEU proto-oncogene
  • epidermal growth factor receptor-related protein
  • p185neu
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • epidermal growth factor receptor type 2
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