EIF3E 产品
(Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
Categories
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}.
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Featured EIF3E Categories
Recommended EIF3E 抗体
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Reactivity
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Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
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WB, IHC
Validations
- (5)
Cat. No.
ABIN2783260
Quantity
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Datasheet
Datasheet
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- (3)
Cat. No.
ABIN561508
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Cat. No.
ABIN7152153
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Datasheet
Recommended EIF3E 蛋白
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Cat. No.
ABIN1352556
Quantity
10 μg
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Cat. No.
ABIN1352558
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10 μg
Datasheet
Datasheet
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HEK-293 Cells
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Cat. No.
ABIN2720079
Quantity
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Datasheet
Datasheet
Latest Publications for our EIF3E Products
: "An oncogenic role of eIF3e/INT6 in human breast cancer." in: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).
: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." in: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).
: "Reconstitution reveals the functional core of mammalian eIF3." in: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).
: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." in: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).
: "A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences." in: Journal of virology, Vol. 79, Issue 15, pp. 10093-6, (2005) (PubMed).
: "Int6 expression can predict survival in early-stage non-small cell lung cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 9, pp. 3198-204, (2005) (PubMed).
: "Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation." in: Molecular biology of the cell, Vol. 11, Issue 11, pp. 4005-18, (2001) (PubMed).
Synonyms and alternative names related to EIF3E
eukaryotic translation initiation factor 3 subunit E (EIF3E), eukaryotic translation initiation factor 3, subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (eif3e), eukaryotic translation initiation factor 3 subunit E L homeolog (eif3e.L), eukaryotic translation initiation factor 3 subunit 6 (LOC692936), eukaryotic translation initiation factor 3 subunit E S homeolog (eif3e.S), eukaryotic translation initiation factor 3, subunit E, a (eif3ea), Eukaryotic translation initiation factor 3 subunit E (eif-3.E), eukaryotic translation initiation factor 3, subunit E, b (eif3eb), eukaryotic translation initiation factor 3 subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (LOC108348260), eukaryotic translation initiation factor 3 subunit E (int6), 48kDa, eIF3-p46, EIF3-P48, eIF3-p48, eif3-p48, eIF3-S6, eIF3e, EIF3S6, Eif3s6, eif3s6, eif3s6-A, eif3s6-B, eif3s6b, EIF3SE, im:7147439, INT6, Int6, QtsA-18056Protein level used designations for EIF3E
- eIF-3 p48
- eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E
- eukaryotic translation initiation factor 3, subunit 6 (48kD)
- eukaryotic translation initiation factor 3, subunit 6 48kDa
- mammary tumor-associated protein INT6
- murine mammary tumor integration site 6 (oncogene homolog)
- viral integration site protein INT-6 homolog
- MMTV integration site 6
- mammary tumor integration site 6
- mammary tumor-associated protein INT-6
- viral integration site protein INT-6
- eukaryotic translation initiation factor 3, subunit 6
- eukaryotic translation initiation factor 3 subunit E-A
- Eukaryotic translation initiation factor 3 subunit 6-A
- eukaryotic translation initiation factor 3 subunit E-B
- Eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit E
- Eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E-like
- eIF3e-B
- eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit 6b
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