EIF2S1 产品
(Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))
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The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2\; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3\; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010].
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Featured EIF2S1 Categories
EIF2S1 抗体
High quality antibodies with extensive validation data.
EIF2S1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
EIF2S1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EIF2S1 抗体
Product
Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (1)
- (7)
Cat. No.
ABIN560711
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (2)
- (13)
Cat. No.
ABIN6255389
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IHC, IHC (p)
Validations
- (7)
Cat. No.
ABIN1497972
Quantity
100 μL
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Recommended EIF2S1 ELISA试剂盒
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Cat. No.
ABIN6966606
Quantity
96 tests
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Recommended EIF2S1 蛋白
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Escherichia coli (E. coli)
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- (1)
Cat. No.
ABIN667786
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Wheat germ
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Cat. No.
ABIN1352542
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420222
Quantity
100 μg
Datasheet
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Latest Publications for our EIF2S1 Products
: "Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78." in: Cell death & disease, Vol. 9, Issue 6, pp. 636, (2018) (PubMed).: "EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes." in: Journal of cellular biochemistry, (2018) (PubMed).
: "Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an ..." in: Molecular cancer, Vol. 15, Issue 1, pp. 46, (2017) (PubMed).
: "Midazolam regulated caspase pathway, endoplasmic reticulum stress, autophagy, and cell cycle to induce apoptosis in MA-10 mouse Leydig tumor cells." in: OncoTargets and therapy, Vol. 9, pp. 2519-33, (2016) (PubMed).
: "The spliceosome is a therapeutic vulnerability in MYC-driven cancer. ..." in: Nature, Vol. 525, Issue 7569, pp. 384-8, (2015) (PubMed).
: "IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR." in: RNA (New York, N.Y.), Vol. 15, Issue 8, pp. 1528-42, (2009) (PubMed).
: "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3955-65, (2006) (PubMed).
: "Identification of a hydrogen peroxide-induced PP1-JNK1-Sp1 signaling pathway for gene regulation." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 291, Issue 5, pp. L983-92, (2006) (PubMed).
: "Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20457-60, (2003) (PubMed).
: "Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha." in: The Journal of biological chemistry, Vol. 264, Issue 34, pp. 20372-84, (1990) (PubMed).
Synonyms and alternative names related to EIF2S1
eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), eukaryotic translation initiation factor 2, subunit 1 alpha a (eif2s1a), eukaryotic translation initiation factor 2 subunit alpha (Eif2s1), eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1), eukaryotic translation initiation factor 2 subunit alpha (eif2s1), eukaryotic translation initiation factor 2 alpha subunit (LOC693063), eukaryotic translation initiation factor 2 alpha subunit (CNI00230), eukaryotic translation initiation factor 2 alpha subunit (THAPSDRAFT_105), Eukaryotic translation initiation factor 2 subunit 1 (if2a), eukaryotic translation initiation factor 2 subunit alpha L homeolog (eif2s1.L), eukaryotic translation Initiation Factor 2alpha (eIF-2alpha), 35kDa, 0910001O23Rik, 2410026C18Rik, CG9946, deIF2alpha, Dmel\\CG9946, EIF-2, eIF-2, eIF-2 a, eIF-2 alpha, EIF-2A, EIF-2alpha, eiF-2alpha, EIF2, eIF2 alpha, eIF2-alpha, EIF2A, Eif2a, eif2a, eIF2a, eIF2alpha, Eif2alpha, Eif2s1, eif2s1l, elF2alpha, fb36a08, IF2A_DROME, l(1)14Cf, l(1)19-153, M(1)8e3-10, M(1)14C, M(1)19-153, wu:fb36a08, zgc:56510Protein level used designations for EIF2S1
- eIF-2-alpha
- eukaryotic translation initiation factor 2 subunit 1
- eukaryotic translation initiation factor 2 subunit alpha
- eukaryotic translation initiation factor 2, subunit 1 alpha
- eukaryotic translation initiation factor 2, subunit 1 alpha, like
- EIF-2A
- EIF-2alpha
- eIF-2A
- eIF-2alpha
- eukaryotic translation initiation factor 2A
- eukaryotic translation initiation factor 2 alpha subunit
- Eukaryotic translation initiation factor 2 subunit 1
- eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
- eukaryotic translation initiation factor 2, subunit 1 (alpha )
- CG9946-PA
- eIF-2alpha-PA
- eukaryotic initiation factor 2alpha
- eukaryotic translation initiation factor 2
- eukaryotic translation initiation factor 2alpha
- minute (1) 14C
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