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EGLN3 蛋白

(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
EGLN3 Protein (AA 1-239) (His tag) EGLN3 Protein (AA 1-239) (His tag) EGLN3 Protein (AA 1-239) (His tag) (ABIN7122748)

EGLN3 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

EGLN3 Protein (AA 94-193) (GST tag) EGLN3 Protein (AA 94-193) (GST tag) EGLN3 Protein (AA 94-193) (GST tag) (ABIN1352451)

EGLN3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

EGLN3 Protein (AA 1-239) (GST tag) EGLN3 Protein (AA 1-239) (GST tag) EGLN3 Protein (AA 1-239) (GST tag) (ABIN1352449)

EGLN3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

EGLN3 蛋白 by Origin

Find EGLN3 蛋白 for a variety of species such as anti-Human EGLN3, anti-Mouse EGLN3. The species listed below are among those available. Click on a link to go to the corresponding products.

EGLN3 蛋白 by Source

Here you will find EGLN3 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

EGLN3 蛋白 by 蛋白类型

Here you can find EGLN3 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

EGLN3 蛋白 by 应用范围

Find EGLN3 蛋白 validated for a specific application such as ELISA, WB, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

EGLN3 蛋白 by 生物活性

Find EGLN3 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular EGLN3 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122748
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352451
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352449
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2129051
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3092387
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136771
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5712938
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2720029
Quantity 20 μg
Datasheet Datasheet

Aliases for EGLN3 蛋白

egl-9 family hypoxia-inducible factor 3 (egln3) 蛋白
egl-9 family hypoxia inducible factor 3 (EGLN3) 蛋白
egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L) 蛋白
egl-9 family hypoxia-inducible factor 3 (Egln3) 蛋白
2610021G09Rik 蛋白
AI505553 蛋白
AI648162 蛋白
EGLN3 蛋白
Hif-p4h-3 蛋白
HIFP4H3 蛋白
HIFPH3 蛋白
PHD-3 蛋白
phd3 蛋白
PHD3 蛋白
Phd3 蛋白
SM-20 蛋白
wu:fj78a08 蛋白
zgc:77019 蛋白
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