EDG4 产品
(Lysophosphatidic Acid Receptor 2 (LPAR2))
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This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
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Featured EDG4 Categories
Recommended EDG4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC (p), ICC
Validations
- (3)
Cat. No.
ABIN1910280
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
- (3)
Cat. No.
ABIN390085
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (2)
Cat. No.
ABIN2177376
Quantity
100 μL
Datasheet
Datasheet
Recommended EDG4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309684
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our EDG4 Products
: "Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device." in: BMC cancer, Vol. 17, Issue 1, pp. 234, (2017) (PubMed).: "LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways." in: PLoS ONE, Vol. 10, Issue 9, pp. e0139094, (2015) (PubMed).
: "LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs." in: Molecular and cellular biochemistry, Vol. 408, Issue 1-2, pp. 147-54, (2015) (PubMed).
: "In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity." in: The Journal of cell biology, Vol. 206, Issue 1, pp. 113-27, (2014) (PubMed).
: "Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G?q-mediated Rho and ?v?6 integrin-dependent activation of TGF-?." in: The American journal of pathology, Vol. 181, Issue 4, pp. 1236-49, (2012) (PubMed).
: "Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture." in: Proteomics, Vol. 10, Issue 1, pp. 141-58, (2010) (PubMed).
: "Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway." in: Cellular signalling, Vol. 21, Issue 4, pp. 523-8, (2009) (PubMed).
: "Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2." in: Cancer research, Vol. 67, Issue 15, pp. 7238-46, (2007) (PubMed).
: "RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, Issue 10, pp. 1612-20, (2007) (PubMed).
: "Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses." in: BMC genomics, Vol. 7, pp. 210, (2006) (PubMed).
Synonyms and alternative names related to EDG4
lysophosphatidic acid receptor 2 (LPAR2), lysophosphatidic acid receptor 2 S homeolog (lpar2.S), G protein-coupled bile acid receptor 1 (GPBAR1), lysophosphatidic acid receptor 2 (Lpar2), growth hormone releasing hormone receptor (GHRHR), lysophosphatidic acid receptor 2a (lpar2a), EDG-4, EDG4, Edg4, Gpbar1, IPA2, LPA-2, LPA2, lpa2, Pbx4, RGD1561336, zgc:101053Protein level used designations for EDG4
- G protein-coupled receptor
- LPA receptor 2
- LPA receptor EDG4
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
- lysophosphatidic acid receptor EDG4
- lysophosphatidic acid receptor Edg-4
- G-protein coupled bile acid receptor 1
- LPA-2
- endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4
- GHRF receptor
- GHRH receptor
- GRF receptor
- growth hormone-releasing hormone receptor
- pituitary growth hormone releasing hormone receptor
- pre-B-cell leukemia transcription factor 4
- lysophosphatidic acid receptor 2
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