(Endothelial Differentiation Related Factor 1 (EDF1))
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. [provided by RefSeq, Jul 2008].
Leidi, Mariotti, Maier: "The effects of silencing EDF-1 in human endothelial cells." in: Atherosclerosis, Vol. 211, Issue 1, pp. 55-60, (2010) (PubMed).
Leidi, Mariotti, Maier: "EDF-1 contributes to the regulation of nitric oxide release in VEGF-treated human endothelial cells." in: European journal of cell biology, Vol. 89, Issue 9, pp. 654-60, (2010) (PubMed).
Leidi, Mariotti, Maier: "Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 16, pp. 2733-42, (2009) (PubMed).