ECT2 产品
(Epithelial Cell Transforming Sequence 2 Oncogene (ECT2))
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The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Featured ECT2 Categories
Recommended ECT2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (3)
Cat. No.
ABIN7165313
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF, FACS
Validations
- (3)
Cat. No.
ABIN185018
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC
Validations
- (4)
Cat. No.
ABIN1858683
Quantity
100 μL
Datasheet
Datasheet
Recommended ECT2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2565141
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420336
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7401986
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ECT2 Products
: "Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients." in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, Vol. 18, Issue 7, pp. 735-42, (2016) (PubMed).: "Elevated levels of epithelial cell transforming sequence 2 predicts poor prognosis for prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 34, Issue 1, pp. 13, (2016) (PubMed).
: "Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner." in: The Journal of biological chemistry, Vol. 280, Issue 43, pp. 36502-9, (2005) (PubMed).
: "MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13158-63, (2005) (PubMed).
: "The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5733-9, (2005) (PubMed).
: "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis." in: The Journal of cell biology, Vol. 147, Issue 5, pp. 921-8, (1999) (PubMed).
Synonyms and alternative names related to ECT2
epithelial cell transforming 2 (ECT2), epithelial cell transforming 2 (ect2), ect2 oncogene (Ect2), epithelial cell transforming 2 S homeolog (ect2.S), epithelial cell transforming 2 (Ect2), AI528536, arhgef31, ARHGEF31, ECT2, ect2, mKIAA4037, xect2Protein level used designations for ECT2
- epithelial cell transforming sequence 2 oncogene
- protein ECT2-like
- epithelial cell-transforming sequence 2 oncogene
- protein ECT2
- epithelial cell transforming sequence 2 oncogene protein
- ect2 oncogene
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