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E2F5 产品

(E2F5)

Categories

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured E2F5 Categories

E2F5 抗体

High quality antibodies with extensive validation data.

E2F5 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended E2F5 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (2)
Cat. No. ABIN733673
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN652951
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7006970
Quantity 20 μL
Datasheet Datasheet

Recommended E2F5 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative DNA-Binding ELISA
Validations
Cat. No. ABIN5648569
Quantity 96 tests
Datasheet Datasheet

Recommended E2F5 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3079243
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3122979
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN2719897
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our E2F5 Products

Sokolova, Fiorino, Zoni, Crippa, Reid, Gariboldi, Pierotti: "The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma." in: Journal of cellular physiology, Vol. 230, Issue 12, pp. 3105-14, (2015) (PubMed).

Nagel, Ehrentraut, Meyer, Kaufmann, Drexler, MacLeod: "NFkB is activated by multiple mechanisms in hairy cell leukemia." in: Genes, chromosomes & cancer, Vol. 54, Issue 7, pp. 418-32, (2015) (PubMed).

Song, Gong, Yan, Hong, Wang, Wu, Li, Li, Cao: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).

Zhao, Wu, Ling, Lin, Fu, Deng, He, Zhong: "Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 1, pp. 465, (2013) (PubMed).

Synonyms and alternative names related to E2F5

E2F transcription factor 5 (E2f5), E2F transcription factor 5 (e2f5), E2F transcription factor 5 (E2F5), AU024671, cb735, E2F-5, E2f-5, E2F4, zgc:111879

Protein level used designations for E2F5

  • transcription factor E2F5
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