E2F5 产品
(E2F5)
Categories
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured E2F5 Categories
Recommended E2F5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN733673
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN652951
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7006970
Quantity
20 μL
Datasheet
Datasheet
Recommended E2F5 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative DNA-Binding ELISA
Validations
Cat. No.
ABIN5648569
Quantity
96 tests
Datasheet
Datasheet
Recommended E2F5 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3079243
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3122979
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN2719897
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our E2F5 Products
: "The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma." in: Journal of cellular physiology, Vol. 230, Issue 12, pp. 3105-14, (2015) (PubMed).: "NFkB is activated by multiple mechanisms in hairy cell leukemia." in: Genes, chromosomes & cancer, Vol. 54, Issue 7, pp. 418-32, (2015) (PubMed).
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." in: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).
: "Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 1, pp. 465, (2013) (PubMed).
Synonyms and alternative names related to E2F5
E2F transcription factor 5 (E2f5), E2F transcription factor 5 (e2f5), E2F transcription factor 5 (E2F5), AU024671, cb735, E2F-5, E2f-5, E2F4, zgc:111879Protein level used designations for E2F5
- transcription factor E2F5
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