E2F4 抗体
(E2F Transcription Factor 4, P107/p130-Binding (E2F4))
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008].
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Latest Publications for our E2F4 抗体
: "ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer." in: Nature communications, Vol. 10, Issue 1, pp. 4632, (2019) (PubMed).: "Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation." in: Molecular and cellular biology, Vol. 32, Issue 14, pp. 2722-37, (2012) (PubMed).
Aliases for E2F4 抗体
E2F transcription factor 4 (E2F4) 抗体E2F transcription factor 4 (E2f4) 抗体
E2F transcription factor 4 S homeolog (e2f4.S) 抗体
E2F transcription factor 4 (e2f4) 抗体
2010111M04Rik 抗体
AI427446 抗体
E2F-4 抗体
e2f-4 抗体
E2F4 抗体
fb72f07 抗体
wu:fb72f07 抗体
wu:fe05f06 抗体
zgc:63815 抗体
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