E2F1 产品
(E2F Transcription Factor 1 (E2F1))
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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].
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Featured E2F1 Categories
E2F1 抗体
High quality antibodies with extensive validation data.
E2F1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
E2F1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended E2F1 抗体
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Cat. No.
ABIN969516
Quantity
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Cat. No.
ABIN7127462
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Cat. No.
ABIN560676
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Recommended E2F1 ELISA试剂盒
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ABIN6955489
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Mouse
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ABIN773114
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96 tests
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Goat
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Recommended E2F1 蛋白
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Wheat germ
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Cat. No.
ABIN1352229
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HEK-293 Cells
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Cat. No.
ABIN2719894
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Escherichia coli (E. coli)
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Latest Publications for our E2F1 Products
: "Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo." in: International journal of oncology, Vol. 57, Issue 3, pp. 697-706, (2020) (PubMed).: "Long-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting." in: Scientific reports, Vol. 7, Issue 1, pp. 10237, (2019) (PubMed).
: "The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α." in: Frontiers in oncology, Vol. 9, pp. 654, (2019) (PubMed).
: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, (2018) (PubMed).
: "Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)." in: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 107, (2018) (PubMed).
: "E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair." in: Oncotarget, Vol. 7, Issue 18, pp. 26275-92, (2018) (PubMed).
: "Dependence of p53-deficient cells on the DHX9 DExH-box helicase." in: Oncotarget, Vol. 8, Issue 19, pp. 30908-30921, (2017) (PubMed).
: "Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24538-24550, (2017) (PubMed).
: "Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease." in: Aging, Vol. 8, Issue 2, pp. 272-90, (2016) (PubMed).
: "GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways." in: International journal of molecular sciences, Vol. 16, Issue 9, pp. 21897-910, (2016) (PubMed).
Synonyms and alternative names related to E2F1
E2F transcription factor 1 (E2f1), E2F transcription factor 1 (E2F1), E2F transcription factor 1 L homeolog (e2f1.L), ATE2FB, CG6376, dE2F, dE2f, dE2F1, dE2f1, de2f1, def21, DmE2F-1, Dmel\\CG6376, Dp, drosE2F1, DRTF1/E2F, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, E2F, e2f, E2F-1, E2F1, E2f1, e2f1, E2FB, E2FB TRANSCRIPTION FACTOR, E2F TRANSCRIPTION FACTOR-1 E2F1, E2F transcription factor 1, Evar(3)164, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, mKIAA4009, RBAP1, RBBP3, RBP3, xE2FProtein level used designations for E2F1
- CG6376-PA
- CG6376-PB
- CG6376-PC
- CG6376-PD
- E2-promoter binding factor
- E2f-PA
- E2f-PB
- E2f-PC
- E2f-PD
- PBR3
- PRB-binding protein E2F-1
- RBAP-1
- RBBP-3
- retinoblastoma-associated protein 1
- retinoblastoma-binding protein 3
- transcription factor E2F1
- E2F-1 transcription factor
- E2F-1
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