Dystrophin 产品
(Dystrophin (DMD))
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The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008].
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Featured Dystrophin Categories
Dystrophin 抗体
High quality antibodies with extensive validation data.
Dystrophin ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Dystrophin 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Dystrophin 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN1679546
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7008615
Quantity
60 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, ELISA
Validations
- (4)
Cat. No.
ABIN515027
Quantity
100 μg
Datasheet
Datasheet
Recommended Dystrophin ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966439
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966438
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955484
Quantity
96 tests
Datasheet
Datasheet
Recommended Dystrophin 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351717
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7420834
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394210
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Dystrophin Products
: "In vivo cerebellar circuit function is disrupted in an mdx mouse model of Duchenne muscular dystrophy." in: Disease models & mechanisms, Vol. 13, Issue 2, (2019) (PubMed).: "Immunohistochemical study on dystrophin expression in CAD-related sudden cardiac death: a marker of early myocardial ischaemia." in: International journal of legal medicine, Vol. 132, Issue 5, pp. 1333-1339, (2018) (PubMed).
: "Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly ..." in: Circulation. Heart failure, Vol. 9, Issue 1, pp. e002081, (2016) (PubMed).
: "Isolation and characterization of neural stem cells from dystrophic mdx mouse." in: Experimental cell research, Vol. 343, Issue 2, pp. 190-207, (2016) (PubMed).
: "Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise." in: Cellular signalling, Vol. 28, Issue 9, pp. 1205-15, (2016) (PubMed).
: "A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis." in: Journal of molecular and cellular cardiology, Vol. 98, pp. 37-47, (2016) (PubMed).
: "Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma." in: Cancer genetics, Vol. 205, Issue 5, pp. 232-41, (2012) (PubMed).
: "Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections." in: The Biochemical journal, Vol. 288 ( Pt 2), pp. 663-8, (1993) (PubMed).
: "A quantitative ELISA for dystrophin." in: Journal of immunological methods, Vol. 161, Issue 1, pp. 23-8, (1993) (PubMed).
Synonyms and alternative names related to Dystrophin
dystrophin (DMD), dystrophin (LOC708073), dystrophin, gene 1 L homeolog (dmd.1.L), dystrophin (LOC465557), dystrophin, gene 1 (dmd.1), dystrophin (dmd), dystrophin, muscular dystrophy (Dmd), dystrophin (Dmd), Dystrophin (Dys), BMD, cb664, CG7240, CG7243, CG7344, CG17750, CG31175, CG34157, CMD3B, det, DKFZp459C1629, DKFZp468A1620, DLP, DLP1, DLP2, DLP3, DLP186, DMD, Dmd, dmd, DmDLP, dmDLP, dmDp186, DmDYS, dmDys, Dmel\\CG34157, DNADMD1, Dp71, Dp117, Dp186, Dp205, Dp427, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, DXSmh7, DXSmh9, dys, GI3046716, IDLP, im:6911785, mdx, MGC79631, MGC83347, pke, RATDMD, zfDYS, zgc:110165Protein level used designations for Dystrophin
- dystrophin (muscular dystrophy, Duchenne and Becker types)
- dystrophin
- Duchenne muscular dystrophy
- dystrophin isoform Dp116
- sap
- sapje
- dystrophin Dp71 isoform
- X-linked muscular dystrophy
- RNDNADMD1
- apodystrophin-3
- apodystrophin-I
- dystrophin transcript variant Dp71e
- dystrophin, muscular dystrophy
- CG34157-PA
- CG34157-PB
- CG34157-PC
- CG34157-PD
- CG34157-PE
- CG34157-PF
- CG34157-PG
- CG34157-PH
- CG34157-PI
- CG34157-PJ
- CG34157-PK
- CG34157-PL
- Dys-PA
- Dys-PB
- Dys-PC
- Dys-PD
- Dys-PE
- Dys-PF
- Dys-PG
- Dys-PH
- Dys-PI
- Dys-PJ
- Dys-PK
- Dys-PL
- Dystrophin-like protein 1
- Dystrophin-like protein 186
- Dystrophin-like protein 2
- Dystrophin-like protein 3
- detached
- dystrophin Dp186
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