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DYRK2 产品

(Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2))

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DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].

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Featured DYRK2 Categories

DYRK2 抗体

High quality antibodies with extensive validation data.

DYRK2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DYRK2 抗体

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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
Cat. No. ABIN563627
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
Cat. No. ABIN563629
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (8)
  • (3)
Cat. No. ABIN391770
Quantity 400 μL
Datasheet Datasheet

Recommended DYRK2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
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Cat. No. ABIN1352208
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352206
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508899
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DYRK2 Products

Mimoto, Imawari, Hirooka, Takeyama, Yoshida: "Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer." in: Oncogene, Vol. 36, Issue 13, pp. 1862-1872, (2017) (PubMed).

Nomura, Suzuki, Takahashi, Terasaki, Kimata, Terasaki, Hamasaki, Kimura, Shimizu, Kondo: "Dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) as a novel marker in T1 high-grade and T2 bladder cancer patients receiving neoadjuvant chemotherapy." in: BMC urology, Vol. 15, pp. 53, (2015) (PubMed).

Moreno, Lara-Chica, Soler-Torronteras, Caro, Medina, Álvarez, Salvatierra, Muñoz, Calzado: "The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143376, (2015) (PubMed).

Enomoto, Yamashita, Yoshinaga, Fukami, Miyahara, Nabeshima, Iwasaki: "Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer." in: Tumour biology, Vol. 35, Issue 11, pp. 11021-5, (2014) (PubMed).

Taira, Mimoto, Kurata, Yamaguchi, Kitagawa, Miki, Yoshida: "DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 859-72, (2012) (PubMed).

Pérez, García-Limones, Zapico, Marina, Schmitz, Muñoz, Calzado: "Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways." in: Journal of molecular cell biology, Vol. 4, Issue 5, pp. 316-30, (2012) (PubMed).

Yamashita, Chujo, Tokuishi, Anami, Miyawaki, Yamamoto, Kawahara: "Expression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2) can be a favorable prognostic marker in pulmonary adenocarcinoma." in: The Journal of thoracic and cardiovascular surgery, Vol. 138, Issue 6, pp. 1303-8, (2009) (PubMed).

Yamashita, Chujo, Moroga, Anami, Tokuishi, Miyawaki, Kawano, Takeno, Yamamoto, Kawahara: "DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer." in: Anticancer research, Vol. 29, Issue 7, pp. 2753-7, (2009) (PubMed).

Varjosalo, Björklund, Cheng, Syvänen, Kivioja, Kilpinen, Sun, Kallioniemi, Stunnenberg, He, Ojala, Taipale: "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." in: Cell, Vol. 133, Issue 3, pp. 537-48, (2008) (PubMed).

Taira, Nihira, Yamaguchi, Miki, Yoshida: "DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage." in: Molecular cell, Vol. 25, Issue 5, pp. 725-38, (2007) (PubMed).

Synonyms and alternative names related to DYRK2

dual specificity tyrosine phosphorylation regulated kinase 2 (DYRK2), dual specificity tyrosine-phosphorylation-regulated kinase 2 (CpipJ_CPIJ014802), dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (dyrk2), dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (Dyrk2), dual specificity tyrosine phosphorylation regulated kinase 2 (Dyrk2), dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), 1810038L18Rik, DYRK2, fc18c09, si:ch211-266a5.8, wu:fa09g03, wu:fc18c09

Protein level used designations for DYRK2

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
  • dual specificity tyrosine-phosphorylation-regulated kinase 2
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