DYRK1A 产品
(Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
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This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].
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Featured DYRK1A Categories
DYRK1A 抗体
High quality antibodies with extensive validation data.
DYRK1A ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DYRK1A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DYRK1A 抗体
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Reactivity
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Cat. No.
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Application
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- (7)
Cat. No.
ABIN560675
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
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- (3)
Cat. No.
ABIN6257024
Quantity
100 μL
Datasheet
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Reactivity
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Application
WB, ELISA, IHC, IF
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Cat. No.
ABIN7188711
Quantity
100 μg
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Recommended DYRK1A ELISA试剂盒
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Cat. No.
ABIN6955470
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96 tests
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Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6955471
Quantity
96 tests
Datasheet
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Analytical Method
Qualitative Cell ELISA
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Cat. No.
ABIN5648036
Quantity
96 tests
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Recommended DYRK1A 蛋白
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- (1)
Cat. No.
ABIN1352200
Quantity
10 μg
Datasheet
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Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399637
Quantity
100 μg
Datasheet
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Reactivity
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Source
Escherichia coli (E. coli)
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ABIN7409281
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Latest Publications for our DYRK1A Products
: "Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A." in: BMC research notes, Vol. 11, Issue 1, pp. 297, (2018) (PubMed).: "Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism." in: Biology open, Vol. 7, Issue 4, (2018) (PubMed).
: "Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation." in: Biochimica et biophysica acta, Vol. 1863, Issue 12, pp. 3015-3026, (2016) (PubMed).
: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." in: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, (2015) (PubMed).
: "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3." in: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 953-70, (2015) (PubMed).
: "DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome." in: EBioMedicine, Vol. 2, Issue 2, pp. 120-34, (2015) (PubMed).
: "Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a." in: Human molecular genetics, Vol. 24, Issue 20, pp. 5687-96, (2015) (PubMed).
: "Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model." in: Pharmacology, biochemistry, and behavior, Vol. 138, pp. 70-9, (2015) (PubMed).
: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, (2014) (PubMed).
: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, (2014) (PubMed).
Synonyms and alternative names related to DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a), dual specificity tyrosine phosphorylation regulated kinase 1A (dyrk1a), dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1a), dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog (dyrk1a.S), 2310043O08Rik, D16Ertd272e, D16Ertd493e, dyrk, DYRK, Dyrk, dyrk1, DYRK1, DYRK1A, ENSMUSG00000074897, Gm10783, hp86, HP86, mmb, mnb, MNB, mnbh, MNBH, Mnbh, Mp86, MRD7, PSK47Protein level used designations for DYRK1A
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- dual specificity tyrosine-phosphorylation-regulated kinase 1A
- minibrain
- protein kinase minibrain homolog
- dual specificity tyrosine-phosphorylation-regulated kinase 1A-like
- MNB/DYRK protein kinase
- dual specificity YAK1-related kinase
- hMNB
- mnb protein kinase homolog hp86
- serine/threonine kinase MNB
- serine/threonine-specific protein kinase
- Dual Specificity Yak1-related kinase
- MNBH
- RP86
- minibrain protein kinase
- Protein kinase minibrain homolog
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