Dynactin 1 产品
(Dynactin 1 (DCTN1))
Categories
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008].
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Featured Dynactin 1 Categories
Dynactin 1 抗体
High quality antibodies with extensive validation data.
Dynactin 1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Dynactin 1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Dynactin 1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, FACS
Validations
- (1)
- (7)
Cat. No.
ABIN184834
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IHC (p)
Validations
- (4)
Cat. No.
ABIN2854663
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7150804
Quantity
100 μL
Datasheet
Datasheet
Recommended Dynactin 1 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
Quantity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882617
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6384464
Quantity
96 tests
Datasheet
Datasheet
Recommended Dynactin 1 蛋白
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Source
Wheat germ
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- (1)
Cat. No.
ABIN1351220
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092040
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131313
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Dynactin 1 Products
: "The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization." in: Molecular biology of the cell, pp. mbcE18020108, (2018) (PubMed).: "Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro." in: American journal of physiology. Heart and circulatory physiology, Vol. 296, Issue 3, pp. H806-14, (2009) (PubMed).
: "Anthrax toxin rafts into cells." in: The Journal of cell biology, Vol. 160, Issue 3, pp. 295-6, (2003) (PubMed).
: "Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3627-45, (2002) (PubMed).
: "NudC associates with Lis1 and the dynein motor at the leading pole of neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 24, pp. RC187, (2001) (PubMed).
: "Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1499-509, (2001) (PubMed).
: "Dynactin increases the processivity of the cytoplasmic dynein motor." in: Nature cell biology, Vol. 2, Issue 1, pp. 20-4, (2000) (PubMed).
: "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization." in: Genomics, Vol. 31, Issue 3, pp. 398-9, (1997) (PubMed).
: "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1634-8, (1995) (PubMed).
: "Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued." in: Nature, Vol. 351, Issue 6327, pp. 579-83, (1991) (PubMed).
Synonyms and alternative names related to Dynactin 1
dynactin subunit 1 (DCTN1), dynactin subunit 1 (Dctn1), dynactin 1 (Dctn1), Dynactin 1, p150 subunit (DCTN1-p150), dynactin subunit 1 L homeolog (dctn1.L), AL022633, CG9206, Chip150, DAP-150, DCTN1, DKFZp469C1813, Dmel\\CG9206, DP-150, Dynactin-1, DYNA_DROME, FCP-D, Glu, Glued, glued, P135, p150, P150, p150/Glued, p150/glued, p150Protein level used designations for Dynactin 1
- 150 kDa dynein-associated polypeptide
- dynactin 1 (p150, glued homolog, Drosophila)
- dynactin subunit 1
- DAP-150
- DP-150
- p150-glued
- dynactin 1
- dynactin subunit 1-like
- dynactin 1, retrograde axonal transport
- CG9206-PA
- Gl-PA
- dynactin
- dynactin P150
- glued
- p150[glued]
- p150glued
- dynactin 1 (p150, glued homolog)
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