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DUSP6 抗体

(Dual Specificity Phosphatase 6 (DUSP6))
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
DUSP6 抗体  (AA 1-381) DUSP6 抗体  (AA 1-381) DUSP6 抗体 (AA 1-381) (ABIN560670)

DUSP6 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3G2 unconjugated

DUSP6 抗体  (AA 1-300) DUSP6 抗体  (AA 1-300) DUSP6 抗体 (AA 1-300) (ABIN7436195)

DUSP6 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

DUSP6 抗体  (AA 58-89) DUSP6 抗体  (AA 58-89) DUSP6 抗体 (AA 58-89) (ABIN392864)

DUSP6 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05814 unconjugated

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DUSP6 抗体 by 适用

Find DUSP6 抗体 for a variety of species such as anti-Human DUSP6, anti-Mouse DUSP6, anti-Rat DUSP6. The species listed below are among those available. Click on a link to go to the corresponding products.

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DUSP6 抗体 by 克隆形成能力

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Popular DUSP6 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p), RNAi
Validations
  • (3)
  • (6)
Cat. No. ABIN560670
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (5)
Cat. No. ABIN7436195
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN392864
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN3017521
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA
Validations
  • (5)
Cat. No. ABIN3030776
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7150781
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6261386
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6261384
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, IHC (p), RNAi
Validations
  • (3)
Cat. No. ABIN574239
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN2856801
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN515108
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN1913720
Quantity 50 μg
Datasheet Datasheet
Reactivity Rat
Application WB, FACS
Validations
  • (3)
  • (2)
Cat. No. ABIN1882185
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (3)
Cat. No. ABIN1539487
Quantity 400 μL
Datasheet Datasheet
Reactivity Cow, Dog, Human, Mouse, Pig, Rat
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7301596
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our DUSP6 抗体

Li, Zhou, Ying, Shi, Cheng, Ren, Griffin, Jia, Li, Moorman, Yao: "Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." in: Hepatology (Baltimore, Md.), (2015) (PubMed).

Kim, Choi, Han, Lee, Soh, Park, Kim, Park: "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1107-20, (2014) (PubMed).

Lee, Huang, Lee, Lee, Ryu, Kim, Kim, Kim, Joung, Kim, Shong, Jo: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).

Geetha, Mihaly, Stockenhuber, Blasi, Uhrin, Binder, Freissmuth, Breuss et al.: "Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ..." in: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25663-74, (2011) (PubMed).

Okudela, Yazawa, Woo, Sakaeda, Ishii, Mitsui, Shimoyamada, Sato, Tajiri, Ogawa, Masuda, Takahashi, Sugimura, Kitamura: "Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis." in: The American journal of pathology, Vol. 175, Issue 2, pp. 867-81, (2009) (PubMed).

Olson, Protheroe, Segar, Scholz: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).

Xu, Furukawa, Kanai, Sunamura, Horii: "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer." in: Journal of human genetics, Vol. 50, Issue 4, pp. 159-67, (2005) (PubMed).

Furukawa, Fujisaki, Yoshida, Kanai, Sunamura, Abe, Takeda, Matsuno, Horii: "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 8, pp. 1034-42, (2005) (PubMed).

Karlsson, Mathers, Dickinson, Mandl, Keyse: "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41882-91, (2004) (PubMed).

Furukawa, Yatsuoka, Youssef, Abe, Yokoyama, Fukushige, Soeda, Hoshi, Hayashi, Sunamura, Kobari, Horii: "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer." in: Cytogenetics and cell genetics, Vol. 82, Issue 3-4, pp. 156-9, (1999) (PubMed).

Aliases for DUSP6 抗体

dual specificity phosphatase 6 (DUSP6) 抗体
dual specificity phosphatase 6 (Dusp6) 抗体
dual specificity phosphatase 6 (dusp6) 抗体
dual specificity phosphatase 6 L homeolog (dusp6.L) 抗体
Dual specificity protein phosphatase 6 (dus6) 抗体
1300019I03Rik 抗体
DUSP6 抗体
dusp6 抗体
HH19 抗体
MKP-3 抗体
MKP3 抗体
Mkp3 抗体
mkp3 抗体
PYST1 抗体
pyst1 抗体
wu:fd99d09 抗体
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