DUSP10 产品
(Dual Specificity Phosphatase 10 (DUSP10))
Categories
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique\; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured DUSP10 Categories
Recommended DUSP10 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN564881
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6257139
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), ICC, IF
Validations
- (3)
Cat. No.
ABIN2855915
Quantity
100 μL
Datasheet
Datasheet
Recommended DUSP10 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6203849
Quantity
96 tests
Datasheet
Datasheet
Recommended DUSP10 蛋白
Latest Publications for our DUSP10 Products
: "mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma." in: Genes & cancer, Vol. 5, Issue 11-12, pp. 393-406, (2015) (PubMed).: "Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML." in: The Journal of experimental medicine, Vol. 211, Issue 6, pp. 1093-108, (2014) (PubMed).
: "Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation." in: Cancer research, Vol. 71, Issue 16, pp. 5535-45, (2011) (PubMed).
: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).
: "Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells." in: American journal of physiology. Renal physiology, Vol. 297, Issue 6, pp. F1622-31, (2009) (PubMed).
: "Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 1, pp. 113-23, (2008) (PubMed).
: "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress." in: The Journal of biological chemistry, Vol. 282, Issue 39, pp. 28395-407, (2007) (PubMed).
: "JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity." in: Molecular and cellular biology, Vol. 25, Issue 19, pp. 8619-30, (2005) (PubMed).
: "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases." in: Oncogene, Vol. 18, Issue 50, pp. 6981-8, (2000) (PubMed).
Synonyms and alternative names related to DUSP10
dual specificity phosphatase 10 (DUSP10), dual specificity phosphatase 10 (Dusp10), 2610306G15Rik, AI158871, DUSP10, MKP-5, Mkp-5, MKP5, Mkp5Protein level used designations for DUSP10
- dual specificity protein phosphatase 10
- dual specificity phosphatase 10
- dual specificity protein phosphatase 10-like
- dual specificity phosphatase MKP-5
- map kinase phosphatase 5
- mitogen-activated protein kinase phosphatase 5
- serine/threonine specific protein phosphatase
- MAP kinase phosphatase 5
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