DUOXA1 产品
(Dual Oxidase Maturation Factor 1 (DUOXA1))
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Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013].
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Featured DUOXA1 Categories
Recommended DUOXA1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN530004
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
Cat. No.
ABIN7150692
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Dog, Human, Pig
Application
WB
Validations
- (1)
Cat. No.
ABIN6747594
Quantity
100 μL
Datasheet
Datasheet
Recommended DUOXA1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352082
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352084
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3127045
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUOXA1 Products
: "DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties." in: Oncogenesis, Vol. 5, Issue 10, pp. e261, (2016) (PubMed).: "Dual oxidase maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation." in: Cell communication and signaling : CCS, Vol. 12, pp. 5, (2014) (PubMed).
: "NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics." in: Breast cancer research and treatment, Vol. 119, Issue 3, pp. 773-86, (2010) (PubMed).
Synonyms and alternative names related to DUOXA1
dual oxidase maturation factor 2 (DUOXA2), dual oxidase maturation factor 1 (DUOXA1), dual oxidase maturation factor 1 (LOC100405759), dual oxidase maturation factor 1 (Duoxa1), BC019755, mol, NIP, Nip, Nip1, NUMBIP, RGD1306601Protein level used designations for DUOXA1
- dual oxidase maturation factor 1
- Numb-interacting protein
- dual oxidase activator 1
- dual oxidase maturation factor 1 alpha
- dual oxidase maturation factor 1 beta
- dual oxidase maturation factor 1 delta
- dual oxidase maturation factor 1 gamma
- homolog of Drosophila Numb-interacting protein
- Numb-interacting protein 1
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