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(Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))
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This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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DREAM 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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Latest Publications for our DREAM Products
: "Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus." in: Psychopharmacology, Vol. 232, Issue 11, pp. 1995-2006, (2015) (PubMed).: "A novel short-term plasticity of intrinsic excitability in the hippocampal CA1 pyramidal cells." in: The Journal of physiology, Vol. 592, Issue Pt 13, pp. 2845-64, (2014) (PubMed).
: "The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 18, pp. 7811-24, (2013) (PubMed).
: "Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis." in: The Journal of comparative neurology, Vol. 522, Issue 3, pp. 609-25, (2013) (PubMed).
: "Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck." in: The Journal of urology, Vol. 189, Issue 4, pp. 1567-73, (2013) (PubMed).
: "Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization." in: The Journal of biological chemistry, Vol. 287, Issue 12, pp. 9640-50, (2012) (PubMed).
: "Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene ..." in: Journal of neurochemistry, Vol. 123, Issue 1, pp. 29-43, (2012) (PubMed).
: "The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice." in: Epilepsia, Vol. 53 Suppl 1, pp. 142-9, (2012) (PubMed).
: "Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons." in: Life sciences, Vol. 91, Issue 7-8, pp. 258-63, (2012) (PubMed).
: "DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons." in: Neuron, Vol. 71, Issue 6, pp. 1102-15, (2011) (PubMed).
Synonyms and alternative names related to DREAM
potassium voltage-gated channel interacting protein 3 (KCNIP3), Kv channel-interacting protein 4 (LOC5568664), calsenilin (CpipJ_CPIJ002549), calsenilin (Tsp_05009), Kv channel interacting protein 3, calsenilin (Kcnip3), potassium voltage-gated channel interacting protein 3 (Kcnip3), Kv channel interacting protein 3b, calsenilin (kcnip3b), Kv channel interacting protein 3, calsenilin (KCNIP3), potassium voltage-gated channel interacting protein 3 (kcnip3), 4933407H12Rik, AI413860, CSEN, Csen, csen, DREAM, Dream, im:7145308, KCHIP3, KChIP3, kcnip3, KCNIP3, R74849, rKChIP3, zgc:73306Protein level used designations for DREAM
- A-type potassium channel modulatory protein 3
- DRE-antagonist modulator
- calsenilin
- calsenilin, presenilin-binding protein, EF hand transcription factor
- kv channel-interacting protein 3
- potassium channel interacting protein 3
- calsenilin, presenilin binding protein, EF hand transcription factor
- A-type potassium channel modulating protein 3
- KChIP3
- calsenilin presenilin-binding protein EF hand transcription factor
- calsenilin, presenilin-binding protein, EF hand transcription fa
- downstream regulatory element-antagonist modulator
- Kv channel interacting protein 3, calsenilin
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